3D reconstruction of coronary artery bifurcations from intravascular ultrasound and angiography

Wei Wu, Usama M. Oguz, Akshat Banga, Shijia Zhao, Anjani Kumar Thota, Vinay Kumar Gadamidi, Charu Hasini Vasa, Khaled M. Harmouch, Abdallah Naser, Xiarepati Tieliwaerdi, Yiannis S. Chatzizisis

Research output: Contribution to journalArticlepeer-review


Coronary bifurcation lesions represent a challenging anatomical subset, and the understanding of their 3D anatomy and plaque composition appears to play a key role in devising the optimal stenting strategy. This study proposes a new approach for the 3D reconstruction of coronary bifurcations and plaque materials by combining intravascular ultrasound (IVUS) and angiography. Three patient-specific silicone bifurcation models were 3D reconstructed and compared to micro-computed tomography (µCT) as the gold standard to test the accuracy and reproducibility of the proposed methodology. The clinical feasibility of the method was investigated in three diseased patient-specific bifurcations of varying anatomical complexity. The IVUS-based 3D reconstructed bifurcation models showed high agreement with the µCT reference models, with r2 values ranging from 0.88 to 0.99. The methodology successfully 3D reconstructed all the patient bifurcations, including plaque materials, in less than 60 min. Our proposed method is a simple, time-efficient, and user-friendly tool for accurate 3D reconstruction of coronary artery bifurcations. It can provide valuable information about bifurcation anatomy and plaque burden in the clinical setting, assisting in bifurcation stent planning and education.

Original languageEnglish (US)
Article number13031
JournalScientific reports
Issue number1
StatePublished - Dec 2023
Externally publishedYes

ASJC Scopus subject areas

  • General


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