4SC-202 as a potential treatment for the pediatric brain tumor medulloblastoma

Shanta M. Messerli; Mariah M. Hoffman; Etienne Z. Gnimpieba; Hella Kohlhof; Ratan D. Bhardwaj

doi:10.3390/brainsci7110147

4SC-202 as a potential treatment for the pediatric brain tumor medulloblastoma

Shanta M. Messerli, Mariah M. Hoffman, Etienne Z. Gnimpieba, Hella Kohlhof, Ratan D. Bhardwaj

Great Plains IDeA-CTR

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

This project involves an examination of the effect of the small molecule inhibitor 4SC-202 on the growth of the pediatric brain cancer medulloblastoma. The small molecule inhibitor 4SC-202 significantly inhibits the viability of the pediatric desmoplastic cerebellar human medulloblastoma cell line DAOY, with an IC₅₀ = 58.1 nM, but does not affect the viability of noncancerous neural stem cells (NSC). 4SC-202 exposure inhibits hedgehog expression in the DAOY cell line. Furthermore, microarray analysis of human medulloblastoma patient tumors indicate significant upregulation of key targets in the Hedgehog signaling pathway and Protein Tyrosine Kinase (PTK7).

Original language	English (US)
Article number	147
Journal	Brain Sciences
Volume	7
Issue number	11
DOIs	https://doi.org/10.3390/brainsci7110147
State	Published - Nov 2017

Keywords

4SC-202
Bioinformatics
Medulloblastoma
Microarray
Pediatric brain tumor

ASJC Scopus subject areas

General Neuroscience

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10.3390/brainsci7110147

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title = "4SC-202 as a potential treatment for the pediatric brain tumor medulloblastoma",

abstract = "This project involves an examination of the effect of the small molecule inhibitor 4SC-202 on the growth of the pediatric brain cancer medulloblastoma. The small molecule inhibitor 4SC-202 significantly inhibits the viability of the pediatric desmoplastic cerebellar human medulloblastoma cell line DAOY, with an IC50 = 58.1 nM, but does not affect the viability of noncancerous neural stem cells (NSC). 4SC-202 exposure inhibits hedgehog expression in the DAOY cell line. Furthermore, microarray analysis of human medulloblastoma patient tumors indicate significant upregulation of key targets in the Hedgehog signaling pathway and Protein Tyrosine Kinase (PTK7).",

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author = "Messerli, {Shanta M.} and Hoffman, {Mariah M.} and Gnimpieba, {Etienne Z.} and Hella Kohlhof and Bhardwaj, {Ratan D.}",

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AU - Gnimpieba, Etienne Z.

AU - Kohlhof, Hella

AU - Bhardwaj, Ratan D.

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AB - This project involves an examination of the effect of the small molecule inhibitor 4SC-202 on the growth of the pediatric brain cancer medulloblastoma. The small molecule inhibitor 4SC-202 significantly inhibits the viability of the pediatric desmoplastic cerebellar human medulloblastoma cell line DAOY, with an IC50 = 58.1 nM, but does not affect the viability of noncancerous neural stem cells (NSC). 4SC-202 exposure inhibits hedgehog expression in the DAOY cell line. Furthermore, microarray analysis of human medulloblastoma patient tumors indicate significant upregulation of key targets in the Hedgehog signaling pathway and Protein Tyrosine Kinase (PTK7).

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KW - Microarray

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4SC-202 as a potential treatment for the pediatric brain tumor medulloblastoma

Abstract

Keywords

ASJC Scopus subject areas

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