TY - JOUR
T1 - 5-HT 2A receptors modulate dopamine D 2 -mediated maternal effects
AU - Gao, Jun
AU - Chen, Leilei
AU - Li, Ming
N1 - Funding Information:
This research was supported by a grant from the National Natural Science Foundation of China (NSFC) (No. 31500891 ) (J. G.), the Fundamental Research Funds for the Central Universities [( SWU1909326 , SWU115030 ) (J. G.), ( SWU116014 ) (M. L.)], the National Institute of Mental Health ( R01MH097718 ) (M. L.), and Chongqing Collaborative Innovation Center for Brain Science , China (M. L.).
Publisher Copyright:
© 2019 Elsevier Inc.
PY - 2019/5
Y1 - 2019/5
N2 - Serotonin 5-HT 2A receptors are expressed throughout the mesolimbic and mesocortical dopamine pathways, and manipulation of this receptor system has a profound impact on dopamine functions and dopamine-mediated behaviors. It is highly likely that 5-HT 2A receptors may also modulate the D 2 -mediated maternal effects. The present study investigated this issue and also explored the possible behavioral mechanisms. We tested the effects of two D 2 drugs (an agonist quinpirole: 0.5, 1.0 mg/kg, and a potent D 2 antagonist haloperidol: 0.05, 0.10 mg/kg, sc) and their combinations with two 5-HT 2A drugs (a selective 5-HT 2A agonist TCB-2: 2.5 mg/kg, and 5-HT 2A antagonist MDL100907, 1.0 mg/kg, sc) on maternal behavior in Sprague-Dawley postpartum females. Individually, TCB-2 (2.5 mg/kg, sc) and quinpirole (0.5 and 1.0 mg/kg, sc) reduced pup preference and disrupted home-cage maternal behavior. In contrast, haloperidol (0.10 mg/kg, sc) only disrupted home-cage maternal behavior, but did not suppress pup preference. MDL100907 (1.0 mg/kg, sc) by itself had no effect on either pup preference or maternal behavior. When administered in combination, pretreatment of TCB-2 did not alter quinpirole's disruption of pup preference and home-cage maternal behavior (possibly due to the floor effect), however, it did enhance haloperidol's disruption of pup retrieval in the home cage. MDL100907 had no effect both quinpirole's and haloperidol's disruption of pup preference and home-cage maternal behavior. Interestingly, haloperidol attenuated TCB-2's disruptive effect on pup preference. These findings suggest that activation of 5-HT 2A receptors tends to enhance D 2 -mediated maternal disruption, whereas blockade of 5-HT 2A receptors is less effective. They also suggest that 5-HT 2A receptors may have a direct effect on maternal behavior independent of their interaction with D 2 receptors. The possible behavioral and neural mechanisms by which 5-HT 2A - and D2-mediated maternal effects and their interaction are discussed.
AB - Serotonin 5-HT 2A receptors are expressed throughout the mesolimbic and mesocortical dopamine pathways, and manipulation of this receptor system has a profound impact on dopamine functions and dopamine-mediated behaviors. It is highly likely that 5-HT 2A receptors may also modulate the D 2 -mediated maternal effects. The present study investigated this issue and also explored the possible behavioral mechanisms. We tested the effects of two D 2 drugs (an agonist quinpirole: 0.5, 1.0 mg/kg, and a potent D 2 antagonist haloperidol: 0.05, 0.10 mg/kg, sc) and their combinations with two 5-HT 2A drugs (a selective 5-HT 2A agonist TCB-2: 2.5 mg/kg, and 5-HT 2A antagonist MDL100907, 1.0 mg/kg, sc) on maternal behavior in Sprague-Dawley postpartum females. Individually, TCB-2 (2.5 mg/kg, sc) and quinpirole (0.5 and 1.0 mg/kg, sc) reduced pup preference and disrupted home-cage maternal behavior. In contrast, haloperidol (0.10 mg/kg, sc) only disrupted home-cage maternal behavior, but did not suppress pup preference. MDL100907 (1.0 mg/kg, sc) by itself had no effect on either pup preference or maternal behavior. When administered in combination, pretreatment of TCB-2 did not alter quinpirole's disruption of pup preference and home-cage maternal behavior (possibly due to the floor effect), however, it did enhance haloperidol's disruption of pup retrieval in the home cage. MDL100907 had no effect both quinpirole's and haloperidol's disruption of pup preference and home-cage maternal behavior. Interestingly, haloperidol attenuated TCB-2's disruptive effect on pup preference. These findings suggest that activation of 5-HT 2A receptors tends to enhance D 2 -mediated maternal disruption, whereas blockade of 5-HT 2A receptors is less effective. They also suggest that 5-HT 2A receptors may have a direct effect on maternal behavior independent of their interaction with D 2 receptors. The possible behavioral and neural mechanisms by which 5-HT 2A - and D2-mediated maternal effects and their interaction are discussed.
KW - Dopamine D receptor
KW - Emotional processing
KW - Incentive motivation
KW - Maternal behavior
KW - Pup preference
KW - Serotonin 2A receptor
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U2 - 10.1016/j.pbb.2019.03.003
DO - 10.1016/j.pbb.2019.03.003
M3 - Article
C2 - 30904543
AN - SCOPUS:85063315000
VL - 180
SP - 32
EP - 43
JO - Pharmacology Biochemistry and Behavior
JF - Pharmacology Biochemistry and Behavior
SN - 0091-3057
ER -