7-OH-DPAT has d-amphetamine-like discriminative stimulus properties

Rick A. Bevins; Jennifer E. Klebaur; Michael T. Bardo

doi:10.1016/S0091-3057(97)00288-8

7-OH-DPAT has d-amphetamine-like discriminative stimulus properties

Rick A. Bevins, Jennifer E. Klebaur, Michael T. Bardo

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Rats were trained on a d-amphetamine (1 mg/kg) vs. saline discrimination task using food-maintained responding (fixed ratio = 25). In extinction tests, drug-appropriate responding decreased as the dose of amphetamine was substituted for the training dose decreased. The dopamine D2/D3 receptor agonist (±)7-hydroxy-N,N-di-n-propyl-2-aminotetralin (7-OH-DPAT) substituted fully for the amphetamine discriminative stimulus at the higher doses examined (0.1, 0.3, 1.0 mg/kg). This substitution was accompanied by a substantial decrease in overall response rates. Eticlopride, a dopamine D2/D3 receptor antagonist, partially blocked 7-OH-DPAT substitution. Thus, at the higher doses, 7-OH-DPAT shared sufficient discriminative stimulus properties with the amphetamine to prompt full substitution. Eticlopride antagonism suggests a role for the D2/D3 dopamine receptor in this substitution.

Original language	English (US)
Pages (from-to)	485-490
Number of pages	6
Journal	Pharmacology Biochemistry and Behavior
Volume	58
Issue number	2
DOIs	https://doi.org/10.1016/S0091-3057(97)00288-8
State	Published - Oct 1997

Keywords

Amphetamine
D2 and D3 receptors
Dopamine
Drug discrimination
Eticlopride
Operant conditioning

ASJC Scopus subject areas

Biochemistry
Toxicology
Pharmacology
Clinical Biochemistry
Biological Psychiatry
Behavioral Neuroscience

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10.1016/S0091-3057(97)00288-8

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title = "7-OH-DPAT has d-amphetamine-like discriminative stimulus properties",

abstract = "Rats were trained on a d-amphetamine (1 mg/kg) vs. saline discrimination task using food-maintained responding (fixed ratio = 25). In extinction tests, drug-appropriate responding decreased as the dose of amphetamine was substituted for the training dose decreased. The dopamine D2/D3 receptor agonist (±)7-hydroxy-N,N-di-n-propyl-2-aminotetralin (7-OH-DPAT) substituted fully for the amphetamine discriminative stimulus at the higher doses examined (0.1, 0.3, 1.0 mg/kg). This substitution was accompanied by a substantial decrease in overall response rates. Eticlopride, a dopamine D2/D3 receptor antagonist, partially blocked 7-OH-DPAT substitution. Thus, at the higher doses, 7-OH-DPAT shared sufficient discriminative stimulus properties with the amphetamine to prompt full substitution. Eticlopride antagonism suggests a role for the D2/D3 dopamine receptor in this substitution.",

keywords = "Amphetamine, D2 and D3 receptors, Dopamine, Drug discrimination, Eticlopride, Operant conditioning",

author = "Bevins, {Rick A.} and Klebaur, {Jennifer E.} and Bardo, {Michael T.}",

note = "Funding Information: This work was funded by USPHS grants DA05312 and DA06924 to M. T. Bardo. R. A. Bevins was supported by a National Research Service Award DA05623 while preparing this report for publication. We thank Melinda Marion, Kalpana Shanmugham and Amy Williamson for their assistance in conducting the experiment. We are also grateful to James Rowlett for helpful discussions of this work and to Thomas Kelly and Patricia Robinet for their comments on an earlier version of this manuscript.",

year = "1997",

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language = "English (US)",

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journal = "Pharmacology Biochemistry and Behavior",

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AU - Bevins, Rick A.

AU - Klebaur, Jennifer E.

AU - Bardo, Michael T.

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PY - 1997/10

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N2 - Rats were trained on a d-amphetamine (1 mg/kg) vs. saline discrimination task using food-maintained responding (fixed ratio = 25). In extinction tests, drug-appropriate responding decreased as the dose of amphetamine was substituted for the training dose decreased. The dopamine D2/D3 receptor agonist (±)7-hydroxy-N,N-di-n-propyl-2-aminotetralin (7-OH-DPAT) substituted fully for the amphetamine discriminative stimulus at the higher doses examined (0.1, 0.3, 1.0 mg/kg). This substitution was accompanied by a substantial decrease in overall response rates. Eticlopride, a dopamine D2/D3 receptor antagonist, partially blocked 7-OH-DPAT substitution. Thus, at the higher doses, 7-OH-DPAT shared sufficient discriminative stimulus properties with the amphetamine to prompt full substitution. Eticlopride antagonism suggests a role for the D2/D3 dopamine receptor in this substitution.

AB - Rats were trained on a d-amphetamine (1 mg/kg) vs. saline discrimination task using food-maintained responding (fixed ratio = 25). In extinction tests, drug-appropriate responding decreased as the dose of amphetamine was substituted for the training dose decreased. The dopamine D2/D3 receptor agonist (±)7-hydroxy-N,N-di-n-propyl-2-aminotetralin (7-OH-DPAT) substituted fully for the amphetamine discriminative stimulus at the higher doses examined (0.1, 0.3, 1.0 mg/kg). This substitution was accompanied by a substantial decrease in overall response rates. Eticlopride, a dopamine D2/D3 receptor antagonist, partially blocked 7-OH-DPAT substitution. Thus, at the higher doses, 7-OH-DPAT shared sufficient discriminative stimulus properties with the amphetamine to prompt full substitution. Eticlopride antagonism suggests a role for the D2/D3 dopamine receptor in this substitution.

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7-OH-DPAT has d-amphetamine-like discriminative stimulus properties

Abstract

Keywords

ASJC Scopus subject areas

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