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  • Jean L Grem
2020

The proteomic landscape of pancreatic ductal adenocarcinoma liver metastases identifies molecular subtypes and associations with clinical response A C

Law, H. C. H., Lagundzin, D., Clement, E. J., Qiao, F., Wagner, Z. S., Krieger, K. L., Costanzo-Garvey, D., Caffrey, T. C., Grem, J. L., DiMaio, D. J., Grandgenett, P. M., Cook, L. M., Fisher, K. W., Yu, F., Hollingsworth, M. A. & Woods, N. T., Mar 1 2020, In : Clinical Cancer Research. 26, 5, p. 1065-1076 12 p.

Research output: Contribution to journalArticle

Open Access
2019
2 Scopus citations

Small bowel adenocarcinoma, version 1.2020

Benson, A. B., Venook, A. P., Al-Hawary, M. M., Arain, M. A., Chen, Y. J., Ciombor, K. K., Cohen, S. A., Cooper, H. S., Deming, D. A., Garrido-Laguna, I., Grem, J. L., Hoffe, S. E., Hubbard, J., Hunt, S., Kamel, A., Kirilcuk, N., Krishnamurthi, S., Messersmith, W. A., Meyerhardt, J., Miller, E. D. & 17 others, Mulcahy, M. F., Steven Nurkin, Md, Ms, N. M. M., Overman, M. J., Parikh, A., Patel, H., Pedersen, K. S., Saltz, L. B., Schneider, C., Shibata, D., Skibber, J. M., Sofocleous, C. T., Stoffel, E. M., Stotsky-Himelfarb, E., Willett, C. G., Johnson-Chilla, A., Gregory, K. M. & Gurski, L. A., Jan 1 2019, In : JNCCN Journal of the National Comprehensive Cancer Network. 17, 9, p. 1109-1133 25 p.

Research output: Contribution to journalReview article

Open Access
4 Scopus citations
2018

5-fluoropyrimidines

Ryan, D. P., Grem, J. & Chabner, B. A., Jan 1 2018, Cancer Chemotherapy, Immunotherapy and Biotherapy: Principles and Practice, Sixth Edition. Wolters Kluwer Health, p. 114-135 22 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Anal Carcinoma, version 2.2018 clinical practice guidelines in Oncology

Benson, A. B., Venook, A. P., Al-Hawary, M. M., Cederquist, L., Chen, Y. J., Ciombor, K. K., Cohen, S., Cooper, H. S., Deming, D., Engstrom, P. F., Grem, J. L., Grothey, A., Hochster, H. S., Hoffe, S., Hunt, S., Kamel, A., Kirilcuk, N., Krishnamurthi, S., Messersmith, W. A., Meyerhardt, J. & 14 others, Mulcahy, M. F., Murphy, J. D., Nurkin, S., Saltz, L., Sharma, S., Shibata, D., Skibber, J. M., Sofocleous, C. T., Stoffel, E. M., Stotsky-Himelfarb, E., Willett, C. G., Wuthrick, E., Gregory, K. M. & Freedman-Cass, D. A., Jul 1 2018, In : JNCCN Journal of the National Comprehensive Cancer Network. 16, 7, p. 852-871 20 p.

Research output: Contribution to journalReview article

61 Scopus citations

NCCN Guidelines ® Insights Colon Cancer, Version 2.2018 Featured Updates to the NCCN Guidelines

Benson, A. B., Venook, A. P., Al-Hawary, M. M., Cederquist, L., Chen, Y. J., Ciombor, K. K., Cohen, S., Cooper, H. S., Deming, D., Engstrom, P. F., Garrido-Laguna, I., Grem, J. L., Grothey, A., Hochster, H. S., Hoffe, S., Hunt, S., Kamel, A., Kirilcuk, N., Krishnamurthi, S., Messersmith, W. A. & 16 others, Meyerhardt, J., Miller, E. D., Mulcahy, M. F., Murphy, J. D., Nurkin, S., Saltz, L., Sharma, S., Shibata, D., Skibber, J. M., Sofocleous, C. T., Stoffel, E. M., Stotsky-Himelfarb, E., Willett, C. G., Wuthrick, E., Gregory, K. M. & Freedman-Cass, D. A., Apr 1 2018, In : JNCCN Journal of the National Comprehensive Cancer Network. 16, 4, p. 359-369 11 p.

Research output: Contribution to journalComment/debate

120 Scopus citations

Organoid profiling identifies common responders to chemotherapy in pancreatic cancer

Tiriac, H., Belleau, P., Engle, D. D., Plenker, D., Deschênes, A., Somerville, T. D. D., Froeling, F. E. M., Burkhart, R. A., Denroche, R. E., Jang, G. H., Miyabayashi, K., Young, C. M., Patel, H., Ma, M., Lacomb, J. F., Palmaira, R. L. D., Javed, A. A., Huynh, J. C., Johnson, M., Arora, K. & 50 others, Robine, N., Shah, M., Sanghvi, R., Goetz, A. B., Lowder, C. Y., Martello, L., Driehuis, E., Lecomte, N., Askan, G., Iacobuzio-Donahue, C. A., Clevers, H., Wood, L. D., Hruban, R. H., Thompson, E., Aguirre, A. J., Wolpin, B. M., Sasson, A., Kim, J., Wu, M., Bucobo, J. C., Allen, P., Sejpal, D. V., Nealon, W., Sullivan, J. D., Winter, J. M., Gimotty, P. A., Grem, J. L., Dimaio, D. J., Buscaglia, J. M., Grandgenett, P. M., Brody, J. R., Hollingsworth, M. A., O’kane, G. M., Notta, F., Kim, E., Crawford, J. M., Devoe, C., Ocean, A., Wolfgang, C. L., Yu, K. H., Li, E., Vakoc, C. R., Hubert, B., Fischer, S. E., Wilson, J. M., Moffitt, R., Knox, J., Krasnitz, A., Gallinger, S. & Tuveson, D. A., Sep 2018, In : Cancer Discovery. 8, 9, p. 1112-1129 18 p.

Research output: Contribution to journalArticle

116 Scopus citations

Phase 2 study of treatment selection based on tumor thymidylate synthase expression in previously untreated patients with metastatic colorectal cancer: A trial of the ECOG-ACRIN Cancer Research Group (E4203)

Meropol, N. J., Feng, Y., Grem, J. L., Mulcahy, M. F., Catalano, P. J., Kauh, J. S., Hall, M. J., Saltzman, J. N., George, T. J., Zangmeister, J., Chiorean, E. G., Cheema, P. S., O'Dwyer, P. J. & Benson, A. B., Feb 15 2018, In : Cancer. 124, 4, p. 688-697 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Rectal cancer, version 2.2018 clinical practice guidelines in Oncology

Benson, A. B., Venook, A. P., Al-Hawary, M. M., Cederquist, L., Chen, Y. J., Ciombor, K. K., Cohen, S., Cooper, H. S., Deming, D., Engstrom, P. F., Grem, J. L., Grothey, A., Hochster, H. S., Hoffe, S., Hunt, S., Kamel, A., Kirilcuk, N., Krishnamurthi, S., Messersmith, W. A., Meyerhardt, J. & 15 others, Mulcahy, M. F., Murphy, J. D., Nurkin, S., Saltz, L., Sharma, S., Shibata, D., Skibber, J. M., Sofocleous, C. T., Stoffel, E. M., Stotsky-Himelfarb, E., Willett, C. G., Wuthrick, E., Freedman-Cass, D. A., Gregory, K. M. & Gurski, L., Jul 1 2018, In : JNCCN Journal of the National Comprehensive Cancer Network. 16, 7, p. 874-901 28 p.

Research output: Contribution to journalReview article

76 Scopus citations
2017

Colon cancer, version 1.2017: Clinical practice guidelines in oncology

Benson, A. B., Venook, A. P., Cederquist, L., Chan, E., Chen, Y. J., Cooper, H. S., Deming, D., Engstrom, P. F., Enzinger, P. C., Fichera, A., Grem, J. L., Grothey, A., Hochster, H. S., Hoffe, S., Hunt, S., Kamel, A., Kirilcuk, N., Krishnamurthi, S., Messersmith, W. A., Mulcahy, M. F. & 13 others, Murphy, J. D., Nurkin, S., Saltz, L., Sharma, S., Shibata, D., Skibber, J. M., Sofocleous, C. T., Stoffel, E. M., Stotsky-Himelfarb, E., Willett, C. G., Wu, C. S., Gregory, K. M. & Freedman-Cass, D., Mar 1 2017, In : JNCCN Journal of the National Comprehensive Cancer Network. 15, 3, p. 370-398 29 p.

Research output: Contribution to journalReview article

Open Access
278 Scopus citations

De Novo lipid synthesis facilitates gemcitabine resistance through endoplasmic reticulum stress in pancreatic cancer

Tadros, S., Shukla, S. K., King, R. J., Gunda, V., Vernucci, E., Abrego, J., Chaika, N. V., Yu, F., Lazenby, A. J., Berim, L., Grem, J., Sasson, A. R. & Singh, P. K., Oct 15 2017, In : Cancer Research. 77, 20, p. 5503-5517 15 p.

Research output: Contribution to journalArticle

30 Scopus citations

Enhancer Reprogramming Promotes Pancreatic Cancer Metastasis

Roe, J. S., Hwang, C. I., Somerville, T. D. D., Milazzo, J. P., Lee, E. J., Da Silva, B., Maiorino, L., Tiriac, H., Young, C. M., Miyabayashi, K., Filippini, D., Creighton, B., Burkhart, R. A., Buscaglia, J. M., Kim, E. J., Grem, J. L., Lazenby, A. J., Grunkemeyer, J. A., Hollingsworth, M. A., Grandgenett, P. M. & 4 others, Egeblad, M., Park, Y., Tuveson, D. A. & Vakoc, C. R., Aug 24 2017, In : Cell. 170, 5, p. 875-888.e20

Research output: Contribution to journalArticle

102 Scopus citations

Erratum: MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer (Cancer Cell (2017) 32(1) (71–87.e7) (S1535610817302544) (10.1016/j.ccell.2017.06.004))

Shukla, S. K., Purohit, V., Mehla, K., Gunda, V., Chaika, N. V., Vernucci, E., King, R. J., Abrego, J., Goode, G. D., Dasgupta, A., Illies, A. L., Gebregiworgis, T., Dai, B., Augustine, J. J., Murthy, D., Attri, K. S., Mashadova, O., Grandgenett, P. M., Powers, R., Ly, Q. P. & 17 others, Lazenby, A. J., Grem, J. L., Yu, F., Matés, J. M., Asara, J. M., Kim, J. W., Hankins, J. H., Weekes, C., Hollingsworth, M. A., Serkova, N. J., Sasson, A. R., Fleming, J. B., Oliveto, J. M., Lyssiotis, C. A., Cantley, L. C., Berim, L. & Singh, P., Sep 11 2017, In : Cancer Cell. 32, 3, 1 p.

Research output: Contribution to journalComment/debate

15 Scopus citations

MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer

Shukla, S. K., Purohit, V., Mehla, K., Gunda, V., Chaika, N. V., Vernucci, E., King, R. J., Abrego, J., Goode, G. D., Dasgupta, A., Illies, A. L., Gebregiworgis, T., Dai, B., Augustine, J. J., Murthy, D., Attri, K. S., Mashadova, O., Grandgenett, P. M., Powers, R., Ly, Q. P. & 17 others, Lazenby, A. J., Grem, J. L., Yu, F., Matés, J. M., Asara, J. M., Kim, J. W., Hankins, J. H., Weekes, C., Hollingsworth, M. A., Serkova, N. J., Sasson, A. R., Fleming, J. B., Oliveto, J. M., Lyssiotis, C. A., Cantley, L. C., Berim, L. & Singh, P. K., Jul 10 2017, In : Cancer Cell. 32, 1, p. 71-87.e7

Research output: Contribution to journalArticle

105 Scopus citations

Pharmacokinetics and Biodistribution of GDC-0449 Loaded Micelles in Normal and Liver Fibrotic Mice

Dutta, R., Kumar, V., Peng, Y., Evande, R. E., Grem, J. L. & Mahato, R. I., Mar 1 2017, In : Pharmaceutical Research. 34, 3, p. 564-578 15 p.

Research output: Contribution to journalArticle

8 Scopus citations
2016

Biochemistry and Clinical Activity of N-(Phosphonacety1)-L-aspartate: A Review

Grem, J. L., King, S. A., O'Dwyer, P. J. & Leyland-Jones, B., Jan 1 2016, In : Cancer Research. 48, 16, p. 4441-4454 14 p.

Research output: Contribution to journalReview article

8 Scopus citations

Oncofetal chondroitin sulfate glycosaminoglycans are key players in integrin signaling and tumor cell motility

Clausen, T. M., Pereira, M. A., Nakouzi, N. A., Oo, H. Z., Agerbæk, M., Lee, S., Ørum-Madsen, M. S., Kristensen, A. R., El-Naggar, A., Grandgenett, P. M., Grem, J. L., Hollingsworth, M. A., Holst, P. J., Theander, T., Sorensen, P. H., Daugaard, M. & Salanti, A., Dec 1 2016, In : Molecular Cancer Research. 14, 12, p. 1288-1299 12 p.

Research output: Contribution to journalArticle

24 Scopus citations

Pharmacogenomics of neurodegenerative diseases: Roles in personalized medicines

Evande, R. E., Dutta, R., Tan, C., Grem, J. L. & Mahato, R. I., Jan 1 2016, Neuroimmune Pharmacology. Springer International Publishing, p. 959-970 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter