Ação da melatonina no tecido cartilaginoso

Translated title of the contribution: The role of melatonin on cartilaginous tissue

Priscila Rodrigues Armijo, Rejane Daniele Reginato, Carla Cristina Maganhin, Luiz Fernando Portugal Fuchs, Ricardo Santos Simões, Edmund Chada Baracat, José Maria Soares

Research output: Contribution to journalShort surveypeer-review

2 Scopus citations


The authors write a review showing the action of melatonin on the cartilaginous tissue and relate its chemical structure, site of synthesis, and receptors. They report that low levels of melatonin in menopause may be an important factor in the pathogenesis of osteoporosis, since its replacement in rats leads to an increase in bone mineral density and the thickness of articular cartilage. It is also suggested a possible beneficial effect of melatonin in the prevention of articular cartilage lesions, which could be related to the blockade of oxidative stress, since products of this stress, in addition to tyrosine residues, are observed in the cartilage tissue degradation in joint diseases. Furthermore, it is related that melatonin enhances cartilage matrix synthesis. These facts indicate that melatonin may be beneficial to the integrity of cartilaginous tissue, since there is a reduced secretion of melatonin with advancing age, which is related to increased incidence of osteoarthritis.

Translated title of the contributionThe role of melatonin on cartilaginous tissue
Original languagePortuguese
Pages (from-to)24-29
Number of pages6
JournalReproducao e Climaterio
Issue number1
StatePublished - 2013
Externally publishedYes


  • Cartilage
  • Melatonin
  • Osteoarthritis
  • Oxidative stress
  • Pineal gland

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Reproductive Medicine
  • Obstetrics and Gynecology


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