A 5-HT(1B) receptor agonist inhibits light-induced suppression of pineal melatonin production

Michael A. Rea; Gary E. Pickard

doi:10.1016/S0006-8993(99)02462-2

A 5-HT(1B) receptor agonist inhibits light-induced suppression of pineal melatonin production

Michael A. Rea, Gary E. Pickard

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Serotonin (5-HT) modulates the phase adjusting effects of light on the mammalian circadian clock through the activation of presynaptic 5-HT(1B) receptors located on retinal terminals in the suprachiasmatic nucleus (SCN). The current study was conducted to determine whether activation of 5-HT(1B) receptors also alters photic regulation of nocturnal pineal melatonin production. Systemic administration of the 5-HT(1B) receptor agonist TFMPP attenuated the inhibitory effect of light on pineal melatonin synthesis in a dose-related manner with an apparent ED₅₀ value of 0.9 mg/kg. The effect of TFMPP on light-induced melatonin suppression was blocked by the 5-HT₁ receptor antagonist, methiothepin, but not by the 5-HT(1A) antagonist, WAY 100,635, consistent with the involvement of 5-HT(1B) receptors. The results are consistent with the interpretation that activation of presynaptic 5-HT(1B) receptors on retinal terminals in the SCN attenuates the effect of light on pineal melatonin production, as well as on circadian phase. Copyright (C) 2000 Elsevier Science B.V.

Original language	English (US)
Pages (from-to)	424-428
Number of pages	5
Journal	Brain Research
Volume	858
Issue number	2
DOIs	https://doi.org/10.1016/S0006-8993(99)02462-2
State	Published - Mar 10 2000
Externally published	Yes

Keywords

5-HT(1B) receptor
Circadian rhythm
Melatonin
Pineal
Retinohypothalamic tract
Suprachiasmatic nucleus

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/S0006-8993(99)02462-2

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title = "A 5-HT(1B) receptor agonist inhibits light-induced suppression of pineal melatonin production",

abstract = "Serotonin (5-HT) modulates the phase adjusting effects of light on the mammalian circadian clock through the activation of presynaptic 5-HT(1B) receptors located on retinal terminals in the suprachiasmatic nucleus (SCN). The current study was conducted to determine whether activation of 5-HT(1B) receptors also alters photic regulation of nocturnal pineal melatonin production. Systemic administration of the 5-HT(1B) receptor agonist TFMPP attenuated the inhibitory effect of light on pineal melatonin synthesis in a dose-related manner with an apparent ED50 value of 0.9 mg/kg. The effect of TFMPP on light-induced melatonin suppression was blocked by the 5-HT1 receptor antagonist, methiothepin, but not by the 5-HT(1A) antagonist, WAY 100,635, consistent with the involvement of 5-HT(1B) receptors. The results are consistent with the interpretation that activation of presynaptic 5-HT(1B) receptors on retinal terminals in the SCN attenuates the effect of light on pineal melatonin production, as well as on circadian phase. Copyright (C) 2000 Elsevier Science B.V.",

keywords = "5-HT(1B) receptor, Circadian rhythm, Melatonin, Pineal, Retinohypothalamic tract, Suprachiasmatic nucleus",

author = "Rea, {Michael A.} and Pickard, {Gary E.}",

note = "Funding Information: The authors wish to thank Ms. Anna Marie Michel and Mr. Matthew Cato for excellent technical assistance. This work was supported by grants from the Air Force Office of Scientific Research AFOSR92-AL-004 (M.A.R.) and the National Institutes of Health NS 35615 (G.E.P.). The animals involved in this study were procured, maintained and used in accordance with the Animal Welfare Act and the Guide for the Care and Use of Laboratory Animals prepared by the Institute for Laboratory Animal Resources, National Science Foundation. ",

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T1 - A 5-HT(1B) receptor agonist inhibits light-induced suppression of pineal melatonin production

AU - Rea, Michael A.

AU - Pickard, Gary E.

N1 - Funding Information: The authors wish to thank Ms. Anna Marie Michel and Mr. Matthew Cato for excellent technical assistance. This work was supported by grants from the Air Force Office of Scientific Research AFOSR92-AL-004 (M.A.R.) and the National Institutes of Health NS 35615 (G.E.P.). The animals involved in this study were procured, maintained and used in accordance with the Animal Welfare Act and the Guide for the Care and Use of Laboratory Animals prepared by the Institute for Laboratory Animal Resources, National Science Foundation.

PY - 2000/3/10

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N2 - Serotonin (5-HT) modulates the phase adjusting effects of light on the mammalian circadian clock through the activation of presynaptic 5-HT(1B) receptors located on retinal terminals in the suprachiasmatic nucleus (SCN). The current study was conducted to determine whether activation of 5-HT(1B) receptors also alters photic regulation of nocturnal pineal melatonin production. Systemic administration of the 5-HT(1B) receptor agonist TFMPP attenuated the inhibitory effect of light on pineal melatonin synthesis in a dose-related manner with an apparent ED50 value of 0.9 mg/kg. The effect of TFMPP on light-induced melatonin suppression was blocked by the 5-HT1 receptor antagonist, methiothepin, but not by the 5-HT(1A) antagonist, WAY 100,635, consistent with the involvement of 5-HT(1B) receptors. The results are consistent with the interpretation that activation of presynaptic 5-HT(1B) receptors on retinal terminals in the SCN attenuates the effect of light on pineal melatonin production, as well as on circadian phase. Copyright (C) 2000 Elsevier Science B.V.

AB - Serotonin (5-HT) modulates the phase adjusting effects of light on the mammalian circadian clock through the activation of presynaptic 5-HT(1B) receptors located on retinal terminals in the suprachiasmatic nucleus (SCN). The current study was conducted to determine whether activation of 5-HT(1B) receptors also alters photic regulation of nocturnal pineal melatonin production. Systemic administration of the 5-HT(1B) receptor agonist TFMPP attenuated the inhibitory effect of light on pineal melatonin synthesis in a dose-related manner with an apparent ED50 value of 0.9 mg/kg. The effect of TFMPP on light-induced melatonin suppression was blocked by the 5-HT1 receptor antagonist, methiothepin, but not by the 5-HT(1A) antagonist, WAY 100,635, consistent with the involvement of 5-HT(1B) receptors. The results are consistent with the interpretation that activation of presynaptic 5-HT(1B) receptors on retinal terminals in the SCN attenuates the effect of light on pineal melatonin production, as well as on circadian phase. Copyright (C) 2000 Elsevier Science B.V.

KW - 5-HT(1B) receptor

KW - Circadian rhythm

KW - Melatonin

KW - Pineal

KW - Retinohypothalamic tract

KW - Suprachiasmatic nucleus

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A 5-HT(1B) receptor agonist inhibits light-induced suppression of pineal melatonin production

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