A 5-HT(1B) receptor agonist inhibits light-induced suppression of pineal melatonin production

Michael A. Rea, Gary E. Pickard

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Serotonin (5-HT) modulates the phase adjusting effects of light on the mammalian circadian clock through the activation of presynaptic 5-HT(1B) receptors located on retinal terminals in the suprachiasmatic nucleus (SCN). The current study was conducted to determine whether activation of 5-HT(1B) receptors also alters photic regulation of nocturnal pineal melatonin production. Systemic administration of the 5-HT(1B) receptor agonist TFMPP attenuated the inhibitory effect of light on pineal melatonin synthesis in a dose-related manner with an apparent ED50 value of 0.9 mg/kg. The effect of TFMPP on light-induced melatonin suppression was blocked by the 5-HT1 receptor antagonist, methiothepin, but not by the 5-HT(1A) antagonist, WAY 100,635, consistent with the involvement of 5-HT(1B) receptors. The results are consistent with the interpretation that activation of presynaptic 5-HT(1B) receptors on retinal terminals in the SCN attenuates the effect of light on pineal melatonin production, as well as on circadian phase. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)424-428
Number of pages5
JournalBrain Research
Volume858
Issue number2
DOIs
StatePublished - Mar 10 2000

Keywords

  • 5-HT(1B) receptor
  • Circadian rhythm
  • Melatonin
  • Pineal
  • Retinohypothalamic tract
  • Suprachiasmatic nucleus

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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