TY - JOUR
T1 - A (9;11)(q34;q13) translocation in a hibernoma
AU - Turaga, Kiran K.
AU - Silva-Lopez, Edibaldo
AU - Sanger, Warren G.
AU - Nelson, Marilu
AU - Hunter, William J.
AU - Miettinen, Markku
AU - Gatalica, Zoran
PY - 2006/10/15
Y1 - 2006/10/15
N2 - The diagnosis of hibernoma has historically been made by histopathologic examination and finding of characteristic brown fat cells with granular multivacuolated cytoplasm. The diagnosis of hibernoma may be complicated, however, because seemingly diagnostic cells could be mistakenly identified as lipoblasts, leading to the erroneous diagnosis of well-differentiated liposarcoma. Cytogenetic alterations in lipomatous tumors are well established and could be used for diagnostic purposes. Previous cytogenetic abnormalities reported in hibernomas have included alteration of 11q13 region. Here, we present a case of a hibernoma with a novel cytogenetic alteration involving a reciprocal translocation between 9q and 11q that was useful in establishing the final diagnosis.
AB - The diagnosis of hibernoma has historically been made by histopathologic examination and finding of characteristic brown fat cells with granular multivacuolated cytoplasm. The diagnosis of hibernoma may be complicated, however, because seemingly diagnostic cells could be mistakenly identified as lipoblasts, leading to the erroneous diagnosis of well-differentiated liposarcoma. Cytogenetic alterations in lipomatous tumors are well established and could be used for diagnostic purposes. Previous cytogenetic abnormalities reported in hibernomas have included alteration of 11q13 region. Here, we present a case of a hibernoma with a novel cytogenetic alteration involving a reciprocal translocation between 9q and 11q that was useful in establishing the final diagnosis.
UR - http://www.scopus.com/inward/record.url?scp=33749141687&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33749141687&partnerID=8YFLogxK
U2 - 10.1016/j.cancergencyto.2006.05.014
DO - 10.1016/j.cancergencyto.2006.05.014
M3 - Article
C2 - 17011989
AN - SCOPUS:33749141687
SN - 0165-4608
VL - 170
SP - 163
EP - 166
JO - Cancer genetics and cytogenetics
JF - Cancer genetics and cytogenetics
IS - 2
ER -