A bereavement support group intervention is longitudinally associated with salutary effects on the CD4 cell count and number of physician visits

Karl Goodkin, Daniel J. Feaster, Deshratn Asthana, Nancy T. Blaney, Mahendra Kumar, Teri Baldewicz, Raymond S. Tuttle, Kevin J. Maher, Marianna K. Baum, Paul Shapshak, Mary Ann Fletcher

Research output: Contribution to journalArticlepeer-review

65 Scopus citations


A randomized, controlled, clinical trial was conducted to examine the impact of a semistructured, 10-week, once weekly, 90-min/session bereavement support group intervention on immunological, neuroendocrine, and clinical health status in human immunodeficiency virus type l-seropositive (HIV-1+) and HIV-1-seronegative (HIV-1-) homosexual men, compared to a standard of care control condition. A total of 119 homosexual men (74 HIV-1+ and 45 HIV-1-) were assessed at baseline, 10 weeks, and 6 months follow-up. At the 6-month follow-up assessment, the intervention groups exhibited significant beneficial effects compared to controls on changes in CD4 cell, total T-lymphocyte, and total lymphocyte counts, when baseline levels, antiretroviral medication use, CDC stage of disease, and other potentially confounding factors were accounted for. There was no statistically significant effect on the CD4/CD8 ratio or on the CD8 cell count. The effect on CD4 cell count was associated with group attendance and with changes in plasma cortisol level. Plasma cortisol levels decreased significantly among intervention subjects, compared to controls. A significantly reduced number of health care visits over the 6-month follow-up period among the intervention subjects supported the clinical relevance of the immunological changes observed for both HIV-1+ and HIV-1- individuals. These results indicate that behavioral interventions may have salutary immunological and clinical health effects following bereavement among HIV-1-infected individuals. The effect in HIV-1- individuals suggests that this bereavement support group intervention might have similar salutary effects in the general population. Potential effects of such interventions on clinical HIV disease progression are of interest and should be studied.

Original languageEnglish (US)
Pages (from-to)382-391
Number of pages10
JournalClinical and diagnostic laboratory immunology
Issue number3
StatePublished - 1998
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Clinical Biochemistry
  • Microbiology (medical)


Dive into the research topics of 'A bereavement support group intervention is longitudinally associated with salutary effects on the CD4 cell count and number of physician visits'. Together they form a unique fingerprint.

Cite this