A call for transparent reporting to optimize the predictive value of preclinical research

Story C. Landis; Susan G. Amara; Khusru Asadullah; Chris P. Austin; Robi Blumenstein; Eileen W. Bradley; Ronald G. Crystal; Robert B. Darnell; Robert J. Ferrante; Howard Fillit; Robert Finkelstein; Marc Fisher; Howard E. Gendelman; Robert M. Golub; John L. Goudreau; Robert A. Gross; Amelie K. Gubitz; Sharon E. Hesterlee; David W. Howells; John Huguenard; Katrina Kelner; Walter Koroshetz; Dimitri Krainc; Stanley E. Lazic; Michael S. Levine; Malcolm R. MacLeod; John M. McCall; Richard T.Moxley Iii; Kalyani Narasimhan; Linda J. Noble; Steve Perrin; John D. Porter; Oswald Steward; Ellis Unger; Ursula Utz; Shai D. Silberberg

doi:10.1038/nature11556

A call for transparent reporting to optimize the predictive value of preclinical research

Story C. Landis, Susan G. Amara, Khusru Asadullah, Chris P. Austin, Robi Blumenstein, Eileen W. Bradley, Ronald G. Crystal, Robert B. Darnell, Robert J. Ferrante, Howard Fillit, Robert Finkelstein, Marc Fisher, Howard E. Gendelman, Robert M. Golub, John L. Goudreau, Robert A. Gross, Amelie K. Gubitz, Sharon E. Hesterlee, David W. Howells, John HuguenardKatrina Kelner, Walter Koroshetz, Dimitri Krainc, Stanley E. Lazic, Michael S. Levine, Malcolm R. MacLeod, John M. McCall, Richard T.Moxley Iii, Kalyani Narasimhan, Linda J. Noble, Steve Perrin, John D. Porter, Oswald Steward, Ellis Unger, Ursula Utz, Shai D. Silberberg

Research output: Contribution to journal › Review article › peer-review

943 Scopus citations

Abstract

The US National Institute of Neurological Disorders and Stroke convened major stakeholders in June 2012 to discuss how to improve the methodological reporting of animal studies in grant applications and publications. The main workshop recommendation is that at a minimum studies should report on sample-size estimation, whether and how animals were randomized, whether investigators were blind to the treatment, and the handling of data. We recognize that achieving a meaningful improvement in the quality of reporting will require a concerted effort by investigators, reviewers, funding agencies and journal editors. Requiring better reporting of animal studies will raise awareness of the importance of rigorous study design to accelerate scientific progress.

Original language	English (US)
Pages (from-to)	187-191
Number of pages	5
Journal	Nature
Volume	490
Issue number	7419
DOIs	https://doi.org/10.1038/nature11556
State	Published - Oct 11 2012

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Landis, S. C., Amara, S. G., Asadullah, K., Austin, C. P., Blumenstein, R., Bradley, E. W., Crystal, R. G., Darnell, R. B., Ferrante, R. J., Fillit, H., Finkelstein, R., Fisher, M., Gendelman, H. E., Golub, R. M., Goudreau, J. L., Gross, R. A., Gubitz, A. K., Hesterlee, S. E., Howells, D. W., ... Silberberg, S. D. (2012). A call for transparent reporting to optimize the predictive value of preclinical research. Nature, 490(7419), 187-191. https://doi.org/10.1038/nature11556

Landis, SC, Amara, SG, Asadullah, K, Austin, CP, Blumenstein, R, Bradley, EW, Crystal, RG, Darnell, RB, Ferrante, RJ, Fillit, H, Finkelstein, R, Fisher, M, Gendelman, HE, Golub, RM, Goudreau, JL, Gross, RA, Gubitz, AK, Hesterlee, SE, Howells, DW, Huguenard, J, Kelner, K, Koroshetz, W, Krainc, D, Lazic, SE, Levine, MS, MacLeod, MR, McCall, JM, Iii, RTM, Narasimhan, K, Noble, LJ, Perrin, S, Porter, JD, Steward, O, Unger, E, Utz, U & Silberberg, SD 2012, 'A call for transparent reporting to optimize the predictive value of preclinical research', Nature, vol. 490, no. 7419, pp. 187-191. https://doi.org/10.1038/nature11556

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abstract = "The US National Institute of Neurological Disorders and Stroke convened major stakeholders in June 2012 to discuss how to improve the methodological reporting of animal studies in grant applications and publications. The main workshop recommendation is that at a minimum studies should report on sample-size estimation, whether and how animals were randomized, whether investigators were blind to the treatment, and the handling of data. We recognize that achieving a meaningful improvement in the quality of reporting will require a concerted effort by investigators, reviewers, funding agencies and journal editors. Requiring better reporting of animal studies will raise awareness of the importance of rigorous study design to accelerate scientific progress.",

author = "Landis, {Story C.} and Amara, {Susan G.} and Khusru Asadullah and Austin, {Chris P.} and Robi Blumenstein and Bradley, {Eileen W.} and Crystal, {Ronald G.} and Darnell, {Robert B.} and Ferrante, {Robert J.} and Howard Fillit and Robert Finkelstein and Marc Fisher and Gendelman, {Howard E.} and Golub, {Robert M.} and Goudreau, {John L.} and Gross, {Robert A.} and Gubitz, {Amelie K.} and Hesterlee, {Sharon E.} and Howells, {David W.} and John Huguenard and Katrina Kelner and Walter Koroshetz and Dimitri Krainc and Lazic, {Stanley E.} and Levine, {Michael S.} and MacLeod, {Malcolm R.} and McCall, {John M.} and Iii, {Richard T.Moxley} and Kalyani Narasimhan and Noble, {Linda J.} and Steve Perrin and Porter, {John D.} and Oswald Steward and Ellis Unger and Ursula Utz and Silberberg, {Shai D.}",

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AU - Golub, Robert M.

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AU - Gross, Robert A.

AU - Gubitz, Amelie K.

AU - Hesterlee, Sharon E.

AU - Howells, David W.

AU - Huguenard, John

AU - Kelner, Katrina

AU - Koroshetz, Walter

AU - Krainc, Dimitri

AU - Lazic, Stanley E.

AU - Levine, Michael S.

AU - MacLeod, Malcolm R.

AU - McCall, John M.

AU - Iii, Richard T.Moxley

AU - Narasimhan, Kalyani

AU - Noble, Linda J.

AU - Perrin, Steve

AU - Porter, John D.

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AU - Silberberg, Shai D.

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A call for transparent reporting to optimize the predictive value of preclinical research

Abstract

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