A Cardiovascular Disease-Linked Gut Microbial Metabolite Acts via Adrenergic Receptors

Ina Nemet; Prasenjit Prasad Saha; Nilaksh Gupta; Weifei Zhu; Kymberleigh A. Romano; Sarah M. Skye; Tomas Cajka; Maradumane L. Mohan; Lin Li; Yuping Wu; Masanori Funabashi; Amanda E. Ramer-Tait; Sathyamangla Venkata Naga Prasad; Oliver Fiehn; Federico E. Rey; W. H.Wilson Tang; Michael A. Fischbach; Joseph A. DiDonato; Stanley L. Hazen

doi:10.1016/j.cell.2020.02.016

A Cardiovascular Disease-Linked Gut Microbial Metabolite Acts via Adrenergic Receptors

Ina Nemet, Prasenjit Prasad Saha, Nilaksh Gupta, Weifei Zhu, Kymberleigh A. Romano, Sarah M. Skye, Tomas Cajka, Maradumane L. Mohan, Lin Li, Yuping Wu, Masanori Funabashi, Amanda E. Ramer-Tait, Sathyamangla Venkata Naga Prasad, Oliver Fiehn, Federico E. Rey, W. H.Wilson Tang, Michael A. Fischbach, Joseph A. DiDonato, Stanley L. Hazen

Food Science and Technology

Research output: Contribution to journal › Article › peer-review

509 Scopus citations

Abstract

A microbially generated metabolite, PAGIn, is associated with cardiovascular disease and death in humans. Studies in animal models provide insights into PAGIn metabolism as well as its effects in driving platelet invasiveness and thrombosis through adrenergic receptors.

Original language	English (US)
Pages (from-to)	862-877.e22
Journal	Cell
Volume	180
Issue number	5
DOIs	https://doi.org/10.1016/j.cell.2020.02.016
State	Published - Mar 5 2020

Keywords

GPCR
adrenergic receptors
cardiovascular disease
gut microbe
metabolomics
thrombosis

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.cell.2020.02.016

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Nemet, I., Saha, P. P., Gupta, N., Zhu, W., Romano, K. A., Skye, S. M., Cajka, T., Mohan, M. L., Li, L., Wu, Y., Funabashi, M., Ramer-Tait, A. E., Naga Prasad, S. V., Fiehn, O., Rey, F. E., Tang, W. H. W., Fischbach, M. A., DiDonato, J. A., & Hazen, S. L. (2020). A Cardiovascular Disease-Linked Gut Microbial Metabolite Acts via Adrenergic Receptors. Cell, 180(5), 862-877.e22. https://doi.org/10.1016/j.cell.2020.02.016

Nemet, I, Saha, PP, Gupta, N, Zhu, W, Romano, KA, Skye, SM, Cajka, T, Mohan, ML, Li, L, Wu, Y, Funabashi, M, Ramer-Tait, AE, Naga Prasad, SV, Fiehn, O, Rey, FE, Tang, WHW, Fischbach, MA, DiDonato, JA & Hazen, SL 2020, 'A Cardiovascular Disease-Linked Gut Microbial Metabolite Acts via Adrenergic Receptors', Cell, vol. 180, no. 5, pp. 862-877.e22. https://doi.org/10.1016/j.cell.2020.02.016

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title = "A Cardiovascular Disease-Linked Gut Microbial Metabolite Acts via Adrenergic Receptors",

abstract = "A microbially generated metabolite, PAGIn, is associated with cardiovascular disease and death in humans. Studies in animal models provide insights into PAGIn metabolism as well as its effects in driving platelet invasiveness and thrombosis through adrenergic receptors.",

keywords = "GPCR, adrenergic receptors, cardiovascular disease, gut microbe, metabolomics, thrombosis",

author = "Ina Nemet and Saha, {Prasenjit Prasad} and Nilaksh Gupta and Weifei Zhu and Romano, {Kymberleigh A.} and Skye, {Sarah M.} and Tomas Cajka and Mohan, {Maradumane L.} and Lin Li and Yuping Wu and Masanori Funabashi and Ramer-Tait, {Amanda E.} and {Naga Prasad}, {Sathyamangla Venkata} and Oliver Fiehn and Rey, {Federico E.} and Tang, {W. H.Wilson} and Fischbach, {Michael A.} and DiDonato, {Joseph A.} and Hazen, {Stanley L.}",

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year = "2020",

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doi = "10.1016/j.cell.2020.02.016",

language = "English (US)",

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AU - Nemet, Ina

AU - Saha, Prasenjit Prasad

AU - Gupta, Nilaksh

AU - Zhu, Weifei

AU - Romano, Kymberleigh A.

AU - Skye, Sarah M.

AU - Cajka, Tomas

AU - Mohan, Maradumane L.

AU - Li, Lin

AU - Wu, Yuping

AU - Funabashi, Masanori

AU - Ramer-Tait, Amanda E.

AU - Naga Prasad, Sathyamangla Venkata

AU - Fiehn, Oliver

AU - Rey, Federico E.

AU - Tang, W. H.Wilson

AU - Fischbach, Michael A.

AU - DiDonato, Joseph A.

AU - Hazen, Stanley L.

PY - 2020/3/5

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KW - cardiovascular disease

KW - gut microbe

KW - metabolomics

KW - thrombosis

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A Cardiovascular Disease-Linked Gut Microbial Metabolite Acts via Adrenergic Receptors

Abstract

Keywords

ASJC Scopus subject areas

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