A Cardiovascular Disease-Linked Gut Microbial Metabolite Acts via Adrenergic Receptors

Ina Nemet, Prasenjit Prasad Saha, Nilaksh Gupta, Weifei Zhu, Kymberleigh A. Romano, Sarah M. Skye, Tomas Cajka, Maradumane L. Mohan, Lin Li, Yuping Wu, Masanori Funabashi, Amanda E. Ramer-Tait, Sathyamangla Venkata Naga Prasad, Oliver Fiehn, Federico E. Rey, W. H.Wilson Tang, Michael A. Fischbach, Joseph A. DiDonato, Stanley L. Hazen

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

A microbially generated metabolite, PAGIn, is associated with cardiovascular disease and death in humans. Studies in animal models provide insights into PAGIn metabolism as well as its effects in driving platelet invasiveness and thrombosis through adrenergic receptors.

Original languageEnglish (US)
Pages (from-to)862-877.e22
JournalCell
Volume180
Issue number5
DOIs
StatePublished - Mar 5 2020

Keywords

  • GPCR
  • adrenergic receptors
  • cardiovascular disease
  • gut microbe
  • metabolomics
  • thrombosis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Nemet, I., Saha, P. P., Gupta, N., Zhu, W., Romano, K. A., Skye, S. M., Cajka, T., Mohan, M. L., Li, L., Wu, Y., Funabashi, M., Ramer-Tait, A. E., Naga Prasad, S. V., Fiehn, O., Rey, F. E., Tang, W. H. W., Fischbach, M. A., DiDonato, J. A., & Hazen, S. L. (2020). A Cardiovascular Disease-Linked Gut Microbial Metabolite Acts via Adrenergic Receptors. Cell, 180(5), 862-877.e22. https://doi.org/10.1016/j.cell.2020.02.016