A Cardiovascular Disease-Linked Gut Microbial Metabolite Acts via Adrenergic Receptors

Ina Nemet; Prasenjit Prasad Saha; Nilaksh Gupta; Weifei Zhu; Kymberleigh A. Romano; Sarah M. Skye; Tomas Cajka; Maradumane L. Mohan; Lin Li; Yuping Wu; Masanori Funabashi; Amanda E. Ramer-Tait; Sathyamangla Venkata Naga Prasad; Oliver Fiehn; Federico E. Rey; W. H.Wilson Tang; Michael A. Fischbach; Joseph A. DiDonato; Stanley L. Hazen

doi:10.1016/j.cell.2020.02.016

A Cardiovascular Disease-Linked Gut Microbial Metabolite Acts via Adrenergic Receptors

Ina Nemet, Prasenjit Prasad Saha, Nilaksh Gupta, Weifei Zhu, Kymberleigh A. Romano, Sarah M. Skye, Tomas Cajka, Maradumane L. Mohan, Lin Li, Yuping Wu, Masanori Funabashi, Amanda E. Ramer-Tait, Sathyamangla Venkata Naga Prasad, Oliver Fiehn, Federico E. Rey, W. H.Wilson Tang, Michael A. Fischbach, Joseph A. DiDonato, Stanley L. Hazen

Food Science and Technology

Research output: Contribution to journal › Article

3 Scopus citations

Abstract

A microbially generated metabolite, PAGIn, is associated with cardiovascular disease and death in humans. Studies in animal models provide insights into PAGIn metabolism as well as its effects in driving platelet invasiveness and thrombosis through adrenergic receptors.

Original language	English (US)
Pages (from-to)	862-877.e22
Journal	Cell
Volume	180
Issue number	5
DOIs	https://doi.org/10.1016/j.cell.2020.02.016
State	Published - Mar 5 2020

Keywords

GPCR
adrenergic receptors
cardiovascular disease
gut microbe
metabolomics
thrombosis

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

Access to Document

10.1016/j.cell.2020.02.016

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Nemet, I., Saha, P. P., Gupta, N., Zhu, W., Romano, K. A., Skye, S. M., Cajka, T., Mohan, M. L., Li, L., Wu, Y., Funabashi, M., Ramer-Tait, A. E., Naga Prasad, S. V., Fiehn, O., Rey, F. E., Tang, W. H. W., Fischbach, M. A., DiDonato, J. A., & Hazen, S. L. (2020). A Cardiovascular Disease-Linked Gut Microbial Metabolite Acts via Adrenergic Receptors. Cell, 180(5), 862-877.e22. https://doi.org/10.1016/j.cell.2020.02.016

A Cardiovascular Disease-Linked Gut Microbial Metabolite Acts via Adrenergic Receptors. / Nemet, Ina; Saha, Prasenjit Prasad; Gupta, Nilaksh; Zhu, Weifei; Romano, Kymberleigh A.; Skye, Sarah M.; Cajka, Tomas; Mohan, Maradumane L.; Li, Lin; Wu, Yuping; Funabashi, Masanori; Ramer-Tait, Amanda E.; Naga Prasad, Sathyamangla Venkata; Fiehn, Oliver; Rey, Federico E.; Tang, W. H.Wilson; Fischbach, Michael A.; DiDonato, Joseph A.; Hazen, Stanley L.

In: Cell, Vol. 180, No. 5, 05.03.2020, p. 862-877.e22.

Research output: Contribution to journal › Article

Nemet, I, Saha, PP, Gupta, N, Zhu, W, Romano, KA, Skye, SM, Cajka, T, Mohan, ML, Li, L, Wu, Y, Funabashi, M, Ramer-Tait, AE, Naga Prasad, SV, Fiehn, O, Rey, FE, Tang, WHW, Fischbach, MA, DiDonato, JA & Hazen, SL 2020, 'A Cardiovascular Disease-Linked Gut Microbial Metabolite Acts via Adrenergic Receptors', Cell, vol. 180, no. 5, pp. 862-877.e22. https://doi.org/10.1016/j.cell.2020.02.016

Nemet, Ina ; Saha, Prasenjit Prasad ; Gupta, Nilaksh ; Zhu, Weifei ; Romano, Kymberleigh A. ; Skye, Sarah M. ; Cajka, Tomas ; Mohan, Maradumane L. ; Li, Lin ; Wu, Yuping ; Funabashi, Masanori ; Ramer-Tait, Amanda E. ; Naga Prasad, Sathyamangla Venkata ; Fiehn, Oliver ; Rey, Federico E. ; Tang, W. H.Wilson ; Fischbach, Michael A. ; DiDonato, Joseph A. ; Hazen, Stanley L. / A Cardiovascular Disease-Linked Gut Microbial Metabolite Acts via Adrenergic Receptors. In: Cell. 2020 ; Vol. 180, No. 5. pp. 862-877.e22.

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abstract = "A microbially generated metabolite, PAGIn, is associated with cardiovascular disease and death in humans. Studies in animal models provide insights into PAGIn metabolism as well as its effects in driving platelet invasiveness and thrombosis through adrenergic receptors.",

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