A case of agnogenic myeloid metaplasia evolving into acute myelogenous leukemia associated with the development of trisomy 11 in bone marrow cells

Chi V. Dang, Peter H. Stein, Daryl R. Gress, Gina A. Dallabetta, Walter L. Bender

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

An 83‐year‐old woman who had a 5‐year history of agnogenic myeloid metaplasia and a previous normal marrow cell karyotype presented with acute myelogenous leukemia (AML) associated with the development of trisomy 11 in 100% of cultured marrow cells. Isolated trisomy 11 in marrow cells has been reported previously in five cases of AML, suggesting that trisomy 11 is a nonrandom chromosomal aberration associated with AML.

Original languageEnglish (US)
Pages (from-to)285-288
Number of pages4
JournalAmerican Journal of Hematology
Volume19
Issue number3
DOIs
StatePublished - Jul 1985
Externally publishedYes

Keywords

  • acute myelogenous leukemia
  • agnogenic myeloid metaplasia
  • trisomy 11

ASJC Scopus subject areas

  • Hematology

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