A case of toxic epidermal necrolysis caused by trimethoprim- sulfamethoxazole

Jharendra P. Rijal; Tiffany Pompa; Smith Giri; Vijaya Raj Bhatt

doi:10.1136/bcr-2013-203163

A case of toxic epidermal necrolysis caused by trimethoprim- sulfamethoxazole

Jharendra P. Rijal, Tiffany Pompa, Smith Giri, Vijaya Raj Bhatt

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Toxic epidermal necrolysis (TEN) is a rare but serious dermatological emergency characterised by diffuse exfoliation of the skin and mucous membranes due to immune mediated destruction of the epidermis which can lead to sepsis and respiratory distress. Trimethoprimsulfamethoxazole is a widely used antibiotic which can rarely lead to TEN. Early diagnosis and aggressive medical care is essential for the reduction of high morbidity and mortality associated with this disease. We present a case of successfully recovered TEN due to trimethoprim-sulfamethoxazole in a 62-year-old woman.

Original language	English (US)
Journal	BMJ case reports
DOIs	https://doi.org/10.1136/bcr-2013-203163
State	Published - Jul 9 2014

ASJC Scopus subject areas

General Medicine

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abstract = "Toxic epidermal necrolysis (TEN) is a rare but serious dermatological emergency characterised by diffuse exfoliation of the skin and mucous membranes due to immune mediated destruction of the epidermis which can lead to sepsis and respiratory distress. Trimethoprimsulfamethoxazole is a widely used antibiotic which can rarely lead to TEN. Early diagnosis and aggressive medical care is essential for the reduction of high morbidity and mortality associated with this disease. We present a case of successfully recovered TEN due to trimethoprim-sulfamethoxazole in a 62-year-old woman.",

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AU - Pompa, Tiffany

AU - Giri, Smith

AU - Raj Bhatt, Vijaya

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N2 - Toxic epidermal necrolysis (TEN) is a rare but serious dermatological emergency characterised by diffuse exfoliation of the skin and mucous membranes due to immune mediated destruction of the epidermis which can lead to sepsis and respiratory distress. Trimethoprimsulfamethoxazole is a widely used antibiotic which can rarely lead to TEN. Early diagnosis and aggressive medical care is essential for the reduction of high morbidity and mortality associated with this disease. We present a case of successfully recovered TEN due to trimethoprim-sulfamethoxazole in a 62-year-old woman.

AB - Toxic epidermal necrolysis (TEN) is a rare but serious dermatological emergency characterised by diffuse exfoliation of the skin and mucous membranes due to immune mediated destruction of the epidermis which can lead to sepsis and respiratory distress. Trimethoprimsulfamethoxazole is a widely used antibiotic which can rarely lead to TEN. Early diagnosis and aggressive medical care is essential for the reduction of high morbidity and mortality associated with this disease. We present a case of successfully recovered TEN due to trimethoprim-sulfamethoxazole in a 62-year-old woman.

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JO - BMJ case reports

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A case of toxic epidermal necrolysis caused by trimethoprim- sulfamethoxazole

Abstract

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