A CD-1 mouse model of infection with Staphylococcus aureus: Influence of gender on infection with MRSA and MSSA isolates

S. J. Yanke, M. E. Olson, H. D. Davies, D. A. Hart

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Staphylococcus aureus is an important pathogen of humans and other animals, causing bacteremia, abscessation, toxemia, and other infectious diseases. An animal model using CD-1 mice was developed to study the pathogenesis of methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-sensitive Staphylococcus aureus (MSSA). When inoculated into the CD-1 mouse model, it was shown that both MSSA isolates, (HR 78 and CSA-1) and MRSA isolates (MRSA 456 and MRSA 457) led to chronic infection of the kidney. Female CD-1 mice inoculated with MRSA 456 proved to be more susceptible to infection and mortality than their male counterparts. Castrated mice became more susceptible to infection than intact male mice, suggesting a hormonal involvement in the infection process.

Original languageEnglish (US)
Pages (from-to)920-926
Number of pages7
JournalCanadian journal of microbiology
Volume46
Issue number10
DOIs
StatePublished - 2000
Externally publishedYes

Keywords

  • Animal model
  • Gender
  • MRSA
  • MSSA
  • Staphylococcus aureus

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Genetics

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