TY - JOUR
T1 - A comparison of pediatric vs. adult patients with the ewing sarcoma family of tumors
AU - Verma, Vivek
AU - Denniston, Kyle A.
AU - Lin, Christopher J.
AU - Lin, Chi
N1 - Publisher Copyright:
© 2017 Verma, Denniston, Lin and Lin.
PY - 2017/5/8
Y1 - 2017/5/8
N2 - Purpose: This study sought to identify differences in clinical characteristics, outcomes, and treatments between adult and pediatric patients with the Ewing sarcoma family of tumors (ESFT).Methods: By using the Surveillance, Epidemiology, and End Results database from 1983 to 2013, 1,870 patients were analyzed (n = 976 pediatric, n = 894 adult). Between the two groups, demographic, tumor, and treatment characteristics were collated and compared. The chi-square test determined differences in proportions of the variables between groups. Survival analysis was performed using the Kaplan-Meier method; distributions were compared using the log-rank test. Univariate and multivariate analyses were performed to examine variables correlating with overall survival (OS), the primary endpoint.Results: Adult patients had a poorer prognosis and were more likely to present with primitive neuroectodermal tumor (PNET) histology, along with distant metastasis and soft tissue primary site. In patients undergoing surgery, radiation therapy (RT) was not associated with higher OS in either children or adults. If no surgery was performed, receipt of RT was associated with higher OS in adults but not children. Adulthood negatively correlated with OS on multivariate analysis when adjusting for potential confounding factors. Other salient factors associated with OS were male gender, metastatic disease, non-extremity bone location, treatment era, and PNET histology. However, when examining the most recent subset (patients treated from 2004 to 2013), RT was associated with improved OS in both pediatrics and adults, which was an independent predictor on multivariate analysis.Conclusion: Adult patients with ESFT have inferior survival compared to pediatric patients, likely related to earlier clinical detection in the latter.
AB - Purpose: This study sought to identify differences in clinical characteristics, outcomes, and treatments between adult and pediatric patients with the Ewing sarcoma family of tumors (ESFT).Methods: By using the Surveillance, Epidemiology, and End Results database from 1983 to 2013, 1,870 patients were analyzed (n = 976 pediatric, n = 894 adult). Between the two groups, demographic, tumor, and treatment characteristics were collated and compared. The chi-square test determined differences in proportions of the variables between groups. Survival analysis was performed using the Kaplan-Meier method; distributions were compared using the log-rank test. Univariate and multivariate analyses were performed to examine variables correlating with overall survival (OS), the primary endpoint.Results: Adult patients had a poorer prognosis and were more likely to present with primitive neuroectodermal tumor (PNET) histology, along with distant metastasis and soft tissue primary site. In patients undergoing surgery, radiation therapy (RT) was not associated with higher OS in either children or adults. If no surgery was performed, receipt of RT was associated with higher OS in adults but not children. Adulthood negatively correlated with OS on multivariate analysis when adjusting for potential confounding factors. Other salient factors associated with OS were male gender, metastatic disease, non-extremity bone location, treatment era, and PNET histology. However, when examining the most recent subset (patients treated from 2004 to 2013), RT was associated with improved OS in both pediatrics and adults, which was an independent predictor on multivariate analysis.Conclusion: Adult patients with ESFT have inferior survival compared to pediatric patients, likely related to earlier clinical detection in the latter.
KW - Ewing sarcoma
KW - Pediatric oncology
KW - Primitive neuroectodermal tumor
KW - Radiation therapy
KW - Survival
UR - http://www.scopus.com/inward/record.url?scp=85020175192&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85020175192&partnerID=8YFLogxK
U2 - 10.3389/fonc.2017.00082
DO - 10.3389/fonc.2017.00082
M3 - Article
C2 - 28534008
AN - SCOPUS:85020175192
SN - 2234-943X
VL - 7
SP - 82
JO - Frontiers in Oncology
JF - Frontiers in Oncology
IS - MAY
M1 - 82
ER -