TY - GEN
T1 - A comparison of statistical approaches for genetic anticipation with application to pancreatic cancer
AU - Havnatzki, Gleh R.
AU - Brand, Randall E.
AU - Haynatzka, Vera R.
AU - Lynch, Henry T.
AU - Sherman, Simon A.
PY - 2007
Y1 - 2007
N2 - Genetic anticipation for a particular disease can involve an earlier age at onset (or, diagnosis), greater severity, and/or a higher number of affected individuals in successive generations within a family. The variable of interest in our study of genetic anticipation was age at diagnosis of pancreatic cancer for different generations, with and without adjustment for time under observation. We compared nonparametric and semiparametric statistical tests for paired data. This comparison was illustrated on an example of familial pancreatic cancer where study subjects were taken from the Pancreatic Cancer Collaborative Registry (PCCR). The nonparametric test performed on our example better than the two semiparametric tests, and was more efficient in detecting risk differences at earlier ages. After adjusting for follow up time, all methods detected genetic anticipation.
AB - Genetic anticipation for a particular disease can involve an earlier age at onset (or, diagnosis), greater severity, and/or a higher number of affected individuals in successive generations within a family. The variable of interest in our study of genetic anticipation was age at diagnosis of pancreatic cancer for different generations, with and without adjustment for time under observation. We compared nonparametric and semiparametric statistical tests for paired data. This comparison was illustrated on an example of familial pancreatic cancer where study subjects were taken from the Pancreatic Cancer Collaborative Registry (PCCR). The nonparametric test performed on our example better than the two semiparametric tests, and was more efficient in detecting risk differences at earlier ages. After adjusting for follow up time, all methods detected genetic anticipation.
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U2 - 10.1109/HICSS.2007.9
DO - 10.1109/HICSS.2007.9
M3 - Conference contribution
AN - SCOPUS:39749130005
SN - 0769527558
SN - 9780769527550
T3 - Proceedings of the Annual Hawaii International Conference on System Sciences
BT - Proceedings of the 40th Annual Hawaii International Conference on System Sciences 2007, HICSS'07
T2 - 40th Annual Hawaii International Conference on System Sciences 2007, HICSS'07
Y2 - 3 January 2007 through 6 January 2007
ER -