A comparison of the effects of sodium saccharin in NBR rats and in intact and castrated male F344 rats

Emily M. Garland; Margaret St John; Makoto Asamoto; Steven H. Eklund; Barbara J. Mattson; Linda S. Johnson; Martin Cano; Samuel M. Cohen

doi:10.1016/0304-3835(94)90037-X

A comparison of the effects of sodium saccharin in NBR rats and in intact and castrated male F344 rats

Emily M. Garland, Margaret St John, Makoto Asamoto, Steven H. Eklund, Barbara J. Mattson, Linda S. Johnson, Martin Cano, Samuel M. Cohen

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

High doses of sodium saccharin (NaSac) increase proliferation in the bladder of the rat, with a male preponderance. The possibility that α_2u-globulin is involved in its mechanism of action was evaluated by feeding it at 7.5% of the diet to NCI-Black-Reiter (NBR) male rats, which do not synthesize liver-derived α_2u-globulin. NaSac affected urinary parameters similarly in F344 and NBR male rats, but NBR rats consumed more water leading to greater urinary volume. NaSac produced less proliferation in NBR than in intact F344 rats, with intermediate changes in castrated F344 males, which had intermediate urinary α_2u-globulin levels.

Original language	English (US)
Pages (from-to)	99-107
Number of pages	9
Journal	Cancer Letters
Volume	78
Issue number	1-3
DOIs	https://doi.org/10.1016/0304-3835(94)90037-X
State	Published - Apr 1 1994

Keywords

Bladder
Proliferation
Rat
Saccharin
α-Globulin

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/0304-3835(94)90037-X

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title = "A comparison of the effects of sodium saccharin in NBR rats and in intact and castrated male F344 rats",

abstract = "High doses of sodium saccharin (NaSac) increase proliferation in the bladder of the rat, with a male preponderance. The possibility that α2u-globulin is involved in its mechanism of action was evaluated by feeding it at 7.5% of the diet to NCI-Black-Reiter (NBR) male rats, which do not synthesize liver-derived α2u-globulin. NaSac affected urinary parameters similarly in F344 and NBR male rats, but NBR rats consumed more water leading to greater urinary volume. NaSac produced less proliferation in NBR than in intact F344 rats, with intermediate changes in castrated F344 males, which had intermediate urinary α2u-globulin levels.",

keywords = "Bladder, Proliferation, Rat, Saccharin, α-Globulin",

author = "Garland, {Emily M.} and John, {Margaret St} and Makoto Asamoto and Eklund, {Steven H.} and Mattson, {Barbara J.} and Johnson, {Linda S.} and Martin Cano and Cohen, {Samuel M.}",

note = "Funding Information: We gratefullya cknowledgeth e expertt echnical assistancoef Jan Wehnera ndT raci Anderson,a nd the assistanceo f Deboraha Coleman with the preparation of this manuscript. We thank MohamadK hachab for his statisticaal nalyseso f the data. This work was supportedi n part by a grantf rom theI nternationaLl ife SciencesIn stitute -North America.",

year = "1994",

month = apr,

day = "1",

doi = "10.1016/0304-3835(94)90037-X",

language = "English (US)",

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AU - Garland, Emily M.

AU - John, Margaret St

AU - Asamoto, Makoto

AU - Eklund, Steven H.

AU - Mattson, Barbara J.

AU - Johnson, Linda S.

AU - Cano, Martin

AU - Cohen, Samuel M.

N1 - Funding Information: We gratefullya cknowledgeth e expertt echnical assistancoef Jan Wehnera ndT raci Anderson,a nd the assistanceo f Deboraha Coleman with the preparation of this manuscript. We thank MohamadK hachab for his statisticaal nalyseso f the data. This work was supportedi n part by a grantf rom theI nternationaLl ife SciencesIn stitute -North America.

PY - 1994/4/1

Y1 - 1994/4/1

N2 - High doses of sodium saccharin (NaSac) increase proliferation in the bladder of the rat, with a male preponderance. The possibility that α2u-globulin is involved in its mechanism of action was evaluated by feeding it at 7.5% of the diet to NCI-Black-Reiter (NBR) male rats, which do not synthesize liver-derived α2u-globulin. NaSac affected urinary parameters similarly in F344 and NBR male rats, but NBR rats consumed more water leading to greater urinary volume. NaSac produced less proliferation in NBR than in intact F344 rats, with intermediate changes in castrated F344 males, which had intermediate urinary α2u-globulin levels.

AB - High doses of sodium saccharin (NaSac) increase proliferation in the bladder of the rat, with a male preponderance. The possibility that α2u-globulin is involved in its mechanism of action was evaluated by feeding it at 7.5% of the diet to NCI-Black-Reiter (NBR) male rats, which do not synthesize liver-derived α2u-globulin. NaSac affected urinary parameters similarly in F344 and NBR male rats, but NBR rats consumed more water leading to greater urinary volume. NaSac produced less proliferation in NBR than in intact F344 rats, with intermediate changes in castrated F344 males, which had intermediate urinary α2u-globulin levels.

KW - Bladder

KW - Proliferation

KW - Rat

KW - Saccharin

KW - α-Globulin

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ER -

A comparison of the effects of sodium saccharin in NBR rats and in intact and castrated male F344 rats

Abstract

Keywords

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