A computational model for the initial stages of cardiac looping

Ashok Ramasubramanian, Kimberly S. Latacha, Larry A. Taber

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Cardiac looping is a vital morphogenetic process that transforms the initially straight heart tube into a curved tube normally directed toward the right side of the embryo. A finite element (FE) model for the initial phase of looping was constructed to investigate possible mechanisms responsible for looping. The model includes realistic material properties, actin orientations, and geometry for the stage 10 chick heart (33hrs of 21 day incubation period). The model is used to select the correct distribution of morphogenetic forces (e.g. growth, cytoskeletal contraction, actin polymerization) responsible for the initial phase of c-looping. This is done by matching (1) experimental and model-predicted global shape changes and (2) experimental and model-predicted local morphogenetic stresses and strains.

Original languageEnglish (US)
Title of host publicationProceedings of the 2005 Summer Bioengineering Conference, 2005 SBC
Number of pages2
StatePublished - 2005
Externally publishedYes
Event2005 Summer Bioengineering Conference - Vail, CO, United States
Duration: Jun 22 2005Jun 26 2005

Publication series

NameProceedings of the 2005 Summer Bioengineering Conference


Conference2005 Summer Bioengineering Conference
Country/TerritoryUnited States
CityVail, CO

ASJC Scopus subject areas

  • Engineering(all)


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