TY - GEN
T1 - A computational model for the initial stages of cardiac looping
AU - Ramasubramanian, Ashok
AU - Latacha, Kimberly S.
AU - Taber, Larry A.
PY - 2005
Y1 - 2005
N2 - Cardiac looping is a vital morphogenetic process that transforms the initially straight heart tube into a curved tube normally directed toward the right side of the embryo. A finite element (FE) model for the initial phase of looping was constructed to investigate possible mechanisms responsible for looping. The model includes realistic material properties, actin orientations, and geometry for the stage 10 chick heart (33hrs of 21 day incubation period). The model is used to select the correct distribution of morphogenetic forces (e.g. growth, cytoskeletal contraction, actin polymerization) responsible for the initial phase of c-looping. This is done by matching (1) experimental and model-predicted global shape changes and (2) experimental and model-predicted local morphogenetic stresses and strains.
AB - Cardiac looping is a vital morphogenetic process that transforms the initially straight heart tube into a curved tube normally directed toward the right side of the embryo. A finite element (FE) model for the initial phase of looping was constructed to investigate possible mechanisms responsible for looping. The model includes realistic material properties, actin orientations, and geometry for the stage 10 chick heart (33hrs of 21 day incubation period). The model is used to select the correct distribution of morphogenetic forces (e.g. growth, cytoskeletal contraction, actin polymerization) responsible for the initial phase of c-looping. This is done by matching (1) experimental and model-predicted global shape changes and (2) experimental and model-predicted local morphogenetic stresses and strains.
UR - http://www.scopus.com/inward/record.url?scp=33646562203&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33646562203&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:33646562203
SN - 0974249211
SN - 9780974249216
T3 - Proceedings of the 2005 Summer Bioengineering Conference
SP - 15
EP - 16
BT - Proceedings of the 2005 Summer Bioengineering Conference, 2005 SBC
T2 - 2005 Summer Bioengineering Conference
Y2 - 22 June 2005 through 26 June 2005
ER -