(Formula Presented) Treatment of primary alkyl triflates or iodides with the potassium salt of diethyl (α-fluoro-α-phenylsulfonylmethyl)phosphonate yields (α-fluoro-α-phenylsulfonylalkyl)phosphonates. These can be cleanly desulfonated, in a matter of minutes, with Na(Hg) in MeOH/THF/NaH2PO4. This two-step procedure complements previously reported triflate displacement approaches to α-nonfluorinated and α,α-difluorinated phosphonates.
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry