Abstract
(Formula Presented) Treatment of primary alkyl triflates or iodides with the potassium salt of diethyl (α-fluoro-α-phenylsulfonylmethyl)phosphonate yields (α-fluoro-α-phenylsulfonylalkyl)phosphonates. These can be cleanly desulfonated, in a matter of minutes, with Na(Hg) in MeOH/THF/NaH2PO4. This two-step procedure complements previously reported triflate displacement approaches to α-nonfluorinated and α,α-difluorinated phosphonates.
Original language | English (US) |
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Pages (from-to) | 2009-2012 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 3 |
Issue number | 13 |
DOIs | |
State | Published - Jun 28 2001 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry