A core-shell metal-organic-framework (MOF)-based smart nanocomposite for efficient NIR/H2O2-responsive photodynamic therapy against hypoxic tumor cells

Hui Juan Cai; Ting Ting Shen; Jian Zhang; Chang Fu Shan; Jian Guo Jia; Xiang Li; Wei Sheng Liu; Yu Tang

doi:10.1039/c7tb00314e

A core-shell metal-organic-framework (MOF)-based smart nanocomposite for efficient NIR/H₂O₂-responsive photodynamic therapy against hypoxic tumor cells

Hui Juan Cai, Ting Ting Shen, Jian Zhang, Chang Fu Shan, Jian Guo Jia, Xiang Li, Wei Sheng Liu, Yu Tang

Research output: Contribution to journal › Article › peer-review

91 Scopus citations

Abstract

Core-shell MOF-based smart nanocomposite UCNPs/MB@ZIF-8@catalase (UCNPs = upconversion nanoparticles; MB = methylene blue; ZIF = zeolitic imidazolate framework) has been constructed for bio-imaging and efficient NIR/H₂O₂-responsive photodynamic therapy against hypoxic tumor cells. The nanoporous MOF shell can prevent aggregation of photosensitizers and serve as an efficient self-sufficient oxygen gas acceptor.

Original language	English (US)
Pages (from-to)	2390-2394
Number of pages	5
Journal	Journal of Materials Chemistry B
Volume	5
Issue number	13
DOIs	https://doi.org/10.1039/c7tb00314e
State	Published - 2017

ASJC Scopus subject areas

General Chemistry
Biomedical Engineering
General Materials Science

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title = "A core-shell metal-organic-framework (MOF)-based smart nanocomposite for efficient NIR/H2O2-responsive photodynamic therapy against hypoxic tumor cells",

abstract = "Core-shell MOF-based smart nanocomposite UCNPs/MB@ZIF-8@catalase (UCNPs = upconversion nanoparticles; MB = methylene blue; ZIF = zeolitic imidazolate framework) has been constructed for bio-imaging and efficient NIR/H2O2-responsive photodynamic therapy against hypoxic tumor cells. The nanoporous MOF shell can prevent aggregation of photosensitizers and serve as an efficient self-sufficient oxygen gas acceptor.",

author = "Cai, {Hui Juan} and Shen, {Ting Ting} and Jian Zhang and Shan, {Chang Fu} and Jia, {Jian Guo} and Xiang Li and Liu, {Wei Sheng} and Yu Tang",

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year = "2017",

doi = "10.1039/c7tb00314e",

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T1 - A core-shell metal-organic-framework (MOF)-based smart nanocomposite for efficient NIR/H2O2-responsive photodynamic therapy against hypoxic tumor cells

AU - Cai, Hui Juan

AU - Shen, Ting Ting

AU - Zhang, Jian

AU - Shan, Chang Fu

AU - Jia, Jian Guo

AU - Li, Xiang

AU - Liu, Wei Sheng

AU - Tang, Yu

N1 - Publisher Copyright: © The Royal Society of Chemistry.

PY - 2017

Y1 - 2017

N2 - Core-shell MOF-based smart nanocomposite UCNPs/MB@ZIF-8@catalase (UCNPs = upconversion nanoparticles; MB = methylene blue; ZIF = zeolitic imidazolate framework) has been constructed for bio-imaging and efficient NIR/H2O2-responsive photodynamic therapy against hypoxic tumor cells. The nanoporous MOF shell can prevent aggregation of photosensitizers and serve as an efficient self-sufficient oxygen gas acceptor.

AB - Core-shell MOF-based smart nanocomposite UCNPs/MB@ZIF-8@catalase (UCNPs = upconversion nanoparticles; MB = methylene blue; ZIF = zeolitic imidazolate framework) has been constructed for bio-imaging and efficient NIR/H2O2-responsive photodynamic therapy against hypoxic tumor cells. The nanoporous MOF shell can prevent aggregation of photosensitizers and serve as an efficient self-sufficient oxygen gas acceptor.

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A core-shell metal-organic-framework (MOF)-based smart nanocomposite for efficient NIR/H₂O₂-responsive photodynamic therapy against hypoxic tumor cells

Abstract

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