A correlative study of in vivo and in vitro labeling index using bromodeoxyuridine in human brain tumors

Kusum Kharbanda, Amit K. Dinda, Chitra Sarkar, Asis K. Karak, Rajiv Dhir, Meera Mathur, Subimal Roy

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

The labeling index (LI) of 216 cases of human brain tumors was determined by the immunohistochemical technique with monoclonal antibody to bromodeoxyuridine (BrdU). The proliferative potential of 110 cases was estimated using the intra-operative intravenous infusion of BrdU at a dose of 200 mg/sq m. In another 106 cases, the in vitro technique of incubating freshly resected tumor tissue fragments with 100 ΜM bromodeoxyuridine was used. The BrdU LI in these tumors was then correlated with the histological types and the data as determined by both the in vivo and in vitro BrdU incorporation were compared. The results indicate that although in vivo and in vitro techniques could possibly provide equivalent data in some histologic types, a clear statistically valid proof however is not apparent from this study.

Original languageEnglish (US)
Pages (from-to)185-190
Number of pages6
JournalJournal of Neuro-Oncology
Volume23
Issue number3
DOIs
StatePublished - Oct 1 1995

Keywords

  • brain neoplasms
  • bromodeoxyuridine
  • cell proliferation
  • labeling index

ASJC Scopus subject areas

  • Oncology
  • Neurology
  • Clinical Neurology
  • Cancer Research

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