TY - JOUR
T1 - A cost of reproduction
T2 - Oxidative stress susceptibility is associated with increased egg production in Drosophila melanogaster
AU - Wang, Yue
AU - Salmon, Adam B.
AU - Harshman, Lawrence G.
N1 - Funding Information:
Appreciation is expressed to Alyson Treadway who initially tested the hypothesis underlying the present study while supported by the Summer Undergraduate Research Experience program (1998) at the University of Nebraska-Lincoln. Mike Roth and Jenny Starr also provided invaluable help and data for this study. Appreciation is also expressed to Robert Arking who suggested the method for testing oxidative stress resistance and to Marc Tatar who provided the Orb stock. Useful feedback was provided by Linda Partridge at the 1999 Max Planck Institute for Demographic Research Workshop on Social and Biological Determinants of Longevity. The present study was supported by a grant from the National Institute of Aging (AG08761).
PY - 2001
Y1 - 2001
N2 - The present study tests the hypothesis that reproduction is correlated with decreased oxidative stress resistance. In numerous species, it has been observed that longevity is negatively correlated with reproduction but the physiological basis of this cost is not well understood. In the present study, female egg production was stimulated by adding live yeast to the surface of Drosophila food. After females were held on yeast-supplemented and unmodified medium for 6-12 days, susceptibility to oxidative stress was measured by exposure to methyl viologen. Added yeast was associated with stress susceptibility of fertile females but not of sterile females. The results of the present study suggest that oxidative stress susceptibility is a physiological cost of reproduction.
AB - The present study tests the hypothesis that reproduction is correlated with decreased oxidative stress resistance. In numerous species, it has been observed that longevity is negatively correlated with reproduction but the physiological basis of this cost is not well understood. In the present study, female egg production was stimulated by adding live yeast to the surface of Drosophila food. After females were held on yeast-supplemented and unmodified medium for 6-12 days, susceptibility to oxidative stress was measured by exposure to methyl viologen. Added yeast was associated with stress susceptibility of fertile females but not of sterile females. The results of the present study suggest that oxidative stress susceptibility is a physiological cost of reproduction.
KW - Cost of reproduction
KW - Drosophila melanogaster
KW - Oxidative stress
KW - Stress resistance
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U2 - 10.1016/S0531-5565(01)00095-X
DO - 10.1016/S0531-5565(01)00095-X
M3 - Article
C2 - 11602209
AN - SCOPUS:0034894745
SN - 0531-5565
VL - 36
SP - 1349
EP - 1359
JO - Experimental Gerontology
JF - Experimental Gerontology
IS - 8
ER -