@article{94a1e18ae1e24423ac9d052fce72f1a4,
title = "A critical review of recent knowledge of alcohol's effects on the immunological response in different tissues",
abstract = "Alcohol misuse contributes to the dysregulation of immune responses and multiorgan dysfunction across various tissues, which are associated with higher risk of morbidity and mortality in people with alcohol use disorders. Organ-specific immune cells, including microglia in the brain, alveolar macrophages in the lungs, and Kupffer cells in the liver, play vital functions in host immune defense through tissue repair and maintenance of homeostasis. However, binge drinking and chronic alcohol misuse impair these immune cells' abilities to regulate inflammatory signaling and metabolism, thus contributing to multiorgan dysfunction. Further complicating these delicate systems, immune cell dysfunction associated with alcohol misuse is exacerbated by aging and gut barrier leakage. This critical review describes recent advances in elucidating the potential mechanisms by which alcohol misuse leads to derangements in host immunity and highlights current gaps in knowledge that may be the focus of future investigations.",
keywords = "alcohol use disorder, immunity, inflammation, multi-organ dysfunction",
author = "Kathryn Crotty and Paige Anton and Coleman, {Leon G.} and Morris, {Niya L.} and Lewis, {Sloan A.} and Samuelson, {Derrick R.} and McMahan, {Rachel H.} and Phillipp Hartmann and Adam Kim and Anuradha Ratna and Pranoti Mandrekar and Wyatt, {Todd A.} and Choudhry, {Mashkoor A.} and Kovacs, {Elizabeth J.} and Rebecca McCullough and Yeligar, {Samantha M.}",
note = "Funding Information: This work was supported in part by grants from the National Institute on Alcohol Abuse and Alcoholism (F31 AA029938) to KMC (ORCID ID: 0000‐0002‐9461‐4032), (R01 AA026086) to SMY (ORCID ID: 0000‐0001‐9309‐0233), (R00 AA025386, R00 AA025386‐05S) to RM (ORCID ID: 0000‐0001‐5341‐7326), (R00 AA026336) to DRS (ORCID ID: 0000‐0002‐5356‐1413), (R13 AA020768) to EJK/MAC (ORCID ID: 0000‐0002‐1152‐7145), and (R21 AA026295) to EJK. Additional support was received from the National Institute of General Medical Sciences (T32 GM008602) to Randy A. Hall and (R35 GM131831) to EJK (ORCID ID: 000‐0002‐9459‐9928), and from the Department of Veterans Affairs: I01 BX004335 to EJK and IK6 BX005962) to TAW. Further, the National Institutes of Health (K12 HD85036), University of California San Diego Altman Clinical and Translational Research Institute (ACTRI)/NIH grant (KL2 TR001444), and Pinnacle Research Award in Liver Diseases (PNC22‐159963) from the American Association for the Study of Liver Diseases Foundation to PH, and (R01 AG018859) to EJK. The contents of this report do not represent the views of the Department of Veterans Affairs or the US Government. Finally, the authors thank Shayaan Kabir for his contribution to Figure 1 . Funding Information: This work was supported in part by grants from the National Institute on Alcohol Abuse and Alcoholism (F31 AA029938) to KMC (ORCID ID: 0000-0002-9461-4032), (R01 AA026086) to SMY (ORCID ID: 0000-0001-9309-0233), (R00 AA025386, R00 AA025386-05S) to RM (ORCID ID: 0000-0001-5341-7326), (R00 AA026336) to DRS (ORCID ID: 0000-0002-5356-1413), (R13 AA020768) to EJK/MAC (ORCID ID: 0000-0002-1152-7145), and (R21 AA026295) to EJK. Additional support was received from the National Institute of General Medical Sciences (T32 GM008602) to Randy A. Hall and (R35 GM131831) to EJK (ORCID ID: 000-0002-9459-9928), and from the Department of Veterans Affairs: I01 BX004335 to EJK and IK6 BX005962) to TAW. Further, the National Institutes of Health (K12 HD85036), University of California San Diego Altman Clinical and Translational Research Institute (ACTRI)/NIH grant (KL2 TR001444), and Pinnacle Research Award in Liver Diseases (PNC22-159963) from the American Association for the Study of Liver Diseases Foundation to PH, and (R01 AG018859) to EJK. The contents of this report do not represent the views of the Department of Veterans Affairs or the US Government. Finally, the authors thank Shayaan Kabir for his contribution to Figure 1. Publisher Copyright: {\textcopyright} 2022 The Authors. Alcohol: Clinical & Experimental Research published by Wiley Periodicals LLC on behalf of Research Society on Alcohol.",
year = "2023",
month = jan,
doi = "10.1111/acer.14979",
language = "English (US)",
volume = "47",
pages = "36--44",
journal = "Alcoholism: Clinical and Experimental Research",
issn = "0145-6008",
publisher = "Wiley-Blackwell",
number = "1",
}