TY - GEN
T1 - A crosstalk-based linear filter in biochemical signal transduction pathways for the internet of bio-things
AU - Laddomada, Massimiliano
AU - Pierobon, Massimiliano
N1 - Publisher Copyright:
© 2015 IEEE.
PY - 2015/8/4
Y1 - 2015/8/4
N2 - Novel emerging tools are allowing the manipulation and control of biological cells and their functions, e.g., sensing, actuation, and communication through biochemical stimuli. These tools have the potential to enable the implementation of manmade networks of biological computing devices, i.e., Internet of Bio-things. In this work, signal transduction pathways, i.e., cells' chemical reactions that process biochemical signals, are proposed for the design of analog linear filters to be utilized as components in the Internet of Bio-things. These filters, which exploit the crosstalk of signal transduction pathways to achieve the desired response, are here modeled and analyzed. The relations between filter properties and biochemical parameters are presented with the goal of designing a notch filter. A preliminary numerical example is also given as proof-of-concept.
AB - Novel emerging tools are allowing the manipulation and control of biological cells and their functions, e.g., sensing, actuation, and communication through biochemical stimuli. These tools have the potential to enable the implementation of manmade networks of biological computing devices, i.e., Internet of Bio-things. In this work, signal transduction pathways, i.e., cells' chemical reactions that process biochemical signals, are proposed for the design of analog linear filters to be utilized as components in the Internet of Bio-things. These filters, which exploit the crosstalk of signal transduction pathways to achieve the desired response, are here modeled and analyzed. The relations between filter properties and biochemical parameters are presented with the goal of designing a notch filter. A preliminary numerical example is also given as proof-of-concept.
KW - Biochemical filter design
KW - crosstalk
KW - internet of bio-things
KW - molecular communication
KW - signal transduction pathway
UR - http://www.scopus.com/inward/record.url?scp=84946019738&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84946019738&partnerID=8YFLogxK
U2 - 10.1109/ICASSP.2015.7179027
DO - 10.1109/ICASSP.2015.7179027
M3 - Conference contribution
AN - SCOPUS:84946019738
T3 - ICASSP, IEEE International Conference on Acoustics, Speech and Signal Processing - Proceedings
SP - 5520
EP - 5524
BT - 2015 IEEE International Conference on Acoustics, Speech, and Signal Processing, ICASSP 2015 - Proceedings
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 40th IEEE International Conference on Acoustics, Speech, and Signal Processing, ICASSP 2015
Y2 - 19 April 2014 through 24 April 2014
ER -