A cryptic BCR-PDGFRB fusion resulting in a chronic myeloid neoplasm with monocytosis and eosinophilia: Anovelfindingwithtreatmentimplications

Sanjeev Kumar Gupta; Nitin Jain; Guilin Tang; Andrew Futreal; Sa A. Wang; Joseph D. Khoury; Richard K. Yang; Hong Fang; Keyur P. Patel; Rajyalakshmi Luthra; Mark Routbort; Bedia A. Barkoh; Wei Chen; Xizeng Mao; Jianhua Zhang; L. Jeffrey Medeiros; Carlos E. Bueso-Ramos; Sanam Loghavi

doi:10.6004/jnccn.2020.7573

A cryptic BCR-PDGFRB fusion resulting in a chronic myeloid neoplasm with monocytosis and eosinophilia: Anovelfindingwithtreatmentimplications

Sanjeev Kumar Gupta, Nitin Jain, Guilin Tang, Andrew Futreal, Sa A. Wang, Joseph D. Khoury, Richard K. Yang, Hong Fang, Keyur P. Patel, Rajyalakshmi Luthra, Mark Routbort, Bedia A. Barkoh, Wei Chen, Xizeng Mao, Jianhua Zhang, L. Jeffrey Medeiros, Carlos E. Bueso-Ramos, Sanam Loghavi

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

RNA-seq was used to identify the partner gene and confirm the presence of a BCR-PDGFRB fusion. Identification of this fusion product resulted in successful treatment and long-term remission of this myeloid neoplasm. Based on our results, we suggest that despite current WHO recommendations, screening for PDGFRB rearrangement in cases of leukocytosis with eosinophilia and no other etiologic explanation is necessary, even if the karyotype is normal.

Original language	English (US)
Pages (from-to)	1300-1304
Number of pages	5
Journal	JNCCN Journal of the National Comprehensive Cancer Network
Volume	18
Issue number	10
DOIs	https://doi.org/10.6004/jnccn.2020.7573
State	Published - Oct 2020
Externally published	Yes

ASJC Scopus subject areas

Oncology

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10.6004/jnccn.2020.7573

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Gupta, S. K., Jain, N., Tang, G., Futreal, A., Wang, S. A., Khoury, J. D., Yang, R. K., Fang, H., Patel, K. P., Luthra, R., Routbort, M., Barkoh, B. A., Chen, W., Mao, X., Zhang, J., Jeffrey Medeiros, L., Bueso-Ramos, C. E., & Loghavi, S. (2020). A cryptic BCR-PDGFRB fusion resulting in a chronic myeloid neoplasm with monocytosis and eosinophilia: Anovelfindingwithtreatmentimplications. JNCCN Journal of the National Comprehensive Cancer Network, 18(10), 1300-1304. https://doi.org/10.6004/jnccn.2020.7573

A cryptic BCR-PDGFRB fusion resulting in a chronic myeloid neoplasm with monocytosis and eosinophilia : Anovelfindingwithtreatmentimplications. / Gupta, Sanjeev Kumar; Jain, Nitin; Tang, Guilin et al.

In: JNCCN Journal of the National Comprehensive Cancer Network, Vol. 18, No. 10, 10.2020, p. 1300-1304.

Research output: Contribution to journal › Article › peer-review

Gupta, SK, Jain, N, Tang, G, Futreal, A, Wang, SA, Khoury, JD, Yang, RK, Fang, H, Patel, KP, Luthra, R, Routbort, M, Barkoh, BA, Chen, W, Mao, X, Zhang, J, Jeffrey Medeiros, L, Bueso-Ramos, CE & Loghavi, S 2020, 'A cryptic BCR-PDGFRB fusion resulting in a chronic myeloid neoplasm with monocytosis and eosinophilia: Anovelfindingwithtreatmentimplications', JNCCN Journal of the National Comprehensive Cancer Network, vol. 18, no. 10, pp. 1300-1304. https://doi.org/10.6004/jnccn.2020.7573

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abstract = "RNA-seq was used to identify the partner gene and confirm the presence of a BCR-PDGFRB fusion. Identification of this fusion product resulted in successful treatment and long-term remission of this myeloid neoplasm. Based on our results, we suggest that despite current WHO recommendations, screening for PDGFRB rearrangement in cases of leukocytosis with eosinophilia and no other etiologic explanation is necessary, even if the karyotype is normal.",

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AU - Futreal, Andrew

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AU - Bueso-Ramos, Carlos E.

AU - Loghavi, Sanam

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A cryptic BCR-PDGFRB fusion resulting in a chronic myeloid neoplasm with monocytosis and eosinophilia: Anovelfindingwithtreatmentimplications

Abstract

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