TY - JOUR
T1 - A Factorial Approach for Optimizing the Design Parameters of a Tissue Attachment Mechanism for Drug Delivery
AU - Sarker, Sunandita
AU - Wankum, Ben
AU - Shimizu, Jeff
AU - Jones, Ryan
AU - Terry, Benjamin
N1 - Funding Information:
Manuscript received November 19, 2020; revised May 8, 2021; accepted May 29, 2021. Date of publication June 7, 2021; date of current version December 23, 2021. This work was supported by Progenity, Inc. (Corresponding author: Sunandita Sarker.) Sunandita Sarker is with the University of Nebraska Lincoln, Lincoln, NE 68588 USA (e-mail: [email protected]). Ben Wankum and Benjamin Terry are with the University of Nebraska Lincoln, USA. Jeff Shimizu and Ryan Jones are with Progenity Inc., USA This article has supplementary downloadable material available at https://doi.org/10.1109/TBME.2021.3086975, provided by the authors. Digital Object Identifier 10.1109/TBME.2021.3086975
Publisher Copyright:
© 1964-2012 IEEE.
PY - 2022/1/1
Y1 - 2022/1/1
N2 - Biological macromolecule drugs or biologics are not suited for commonly preferred oral delivery due to their intrinsic instability and physical, chemical, or immunological barriers to the gastrointestinal tract. Ingestible capsule robots (ICR) have become a versatile platform, including use for drug delivery applications for various gastrointestinal pathologies with future potential for systemic drug delivery. In this work, a tissue attachment mechanism (TAM) for a drug delivery ICR is introduced that can facilitate a non-invasive systemic delivery of unaltered biologics via direct injection through the insensate layers of the small intestine. The main prerequisite for achieving systemic drug delivery via this device is to have a strong tissue attachment of the TAM. This study aimed to optimize the attachment success rate for drug delivery and characterize attachment duration in vivo. A fractional factorial approach was used in vivo to identify and optimize factors that most influence attachment of the TAM to maximize attachment rate. Multiple in vivo optimization levels were performed using the small intestine of anesthetized pigs, and an attachment success rate of 92% was achieved. Optimal TAMs were surgically placed in vivo to determine the duration of attachment following anesthetization and surgery recovery. The average in vivo attachment duration was 32.2±9.4 hours. This work establishes a device for consistent and reliable attachment duration, making the TAM a suitable candidate for a 24-hour systemic drug delivery platform.
AB - Biological macromolecule drugs or biologics are not suited for commonly preferred oral delivery due to their intrinsic instability and physical, chemical, or immunological barriers to the gastrointestinal tract. Ingestible capsule robots (ICR) have become a versatile platform, including use for drug delivery applications for various gastrointestinal pathologies with future potential for systemic drug delivery. In this work, a tissue attachment mechanism (TAM) for a drug delivery ICR is introduced that can facilitate a non-invasive systemic delivery of unaltered biologics via direct injection through the insensate layers of the small intestine. The main prerequisite for achieving systemic drug delivery via this device is to have a strong tissue attachment of the TAM. This study aimed to optimize the attachment success rate for drug delivery and characterize attachment duration in vivo. A fractional factorial approach was used in vivo to identify and optimize factors that most influence attachment of the TAM to maximize attachment rate. Multiple in vivo optimization levels were performed using the small intestine of anesthetized pigs, and an attachment success rate of 92% was achieved. Optimal TAMs were surgically placed in vivo to determine the duration of attachment following anesthetization and surgery recovery. The average in vivo attachment duration was 32.2±9.4 hours. This work establishes a device for consistent and reliable attachment duration, making the TAM a suitable candidate for a 24-hour systemic drug delivery platform.
KW - Capsule robots
KW - drug delivery
KW - fractional factorial optimization
KW - tissue attachment
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U2 - 10.1109/TBME.2021.3086975
DO - 10.1109/TBME.2021.3086975
M3 - Article
C2 - 34097601
AN - SCOPUS:85111003772
SN - 0018-9294
VL - 69
SP - 32
EP - 41
JO - IEEE Transactions on Biomedical Engineering
JF - IEEE Transactions on Biomedical Engineering
IS - 1
ER -