A frequency analysis on calcium T-type signaling in the nervous system

Alireza Khodaei; Hamid Vakilzadian; Massimiliano Pierobon

doi:10.1109/EIT.2017.8053442

A frequency analysis on calcium T-type signaling in the nervous system

Alireza Khodaei, Hamid Vakilzadian, Massimiliano Pierobon

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

We expressed the importance of frequency characteristics of T-type calcium signaling in every level of the nervous system. We also highlighted the need for performing frequency analysis on calcium signals in order to understand their impact on various functions within the nervous system. We provided the necessary analytical and computational frameworks for doing power spectral density (PSD) analysis of calcium T-type signals. For this purpose, we modeled a calcium T-type channel gating mechanism using a Markov scheme and formulated the calcium ionic current with the help of some empirical data. Our analysis shows calcium T-type current fades out rapidly at an exponential rate when frequency is increased but decreases almost linearly with depolarization of the membrane.

Original language	English (US)
Title of host publication	2017 IEEE International Conference on Electro Information Technology, EIT 2017
Publisher	IEEE Computer Society
Pages	640-644
Number of pages	5
ISBN (Electronic)	9781509047673
DOIs	https://doi.org/10.1109/EIT.2017.8053442
State	Published - Sep 27 2017
Event	2017 IEEE International Conference on Electro Information Technology, EIT 2017 - Lincoln, United States Duration: May 14 2017 → May 17 2017

Publication series

Name	IEEE International Conference on Electro Information Technology
ISSN (Print)	2154-0357
ISSN (Electronic)	2154-0373

Other

Other	2017 IEEE International Conference on Electro Information Technology, EIT 2017
Country/Territory	United States
City	Lincoln
Period	5/14/17 → 5/17/17

Keywords

Calcium Markov Process
Calcium Monte Carlo Simulation
Calcium Signaling
Calcium T-type Channels
Frequency Analysis
Neurons
Power Spectral Density

ASJC Scopus subject areas

Computer Science Applications
Information Systems
Control and Systems Engineering
Electrical and Electronic Engineering

Access to Document

10.1109/EIT.2017.8053442

Cite this

A frequency analysis on calcium T-type signaling in the nervous system. / Khodaei, Alireza; Vakilzadian, Hamid; Pierobon, Massimiliano.
2017 IEEE International Conference on Electro Information Technology, EIT 2017. IEEE Computer Society, 2017. p. 640-644 8053442 (IEEE International Conference on Electro Information Technology).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Khodaei, A, Vakilzadian, H & Pierobon, M 2017, A frequency analysis on calcium T-type signaling in the nervous system. in 2017 IEEE International Conference on Electro Information Technology, EIT 2017., 8053442, IEEE International Conference on Electro Information Technology, IEEE Computer Society, pp. 640-644, 2017 IEEE International Conference on Electro Information Technology, EIT 2017, Lincoln, United States, 5/14/17. https://doi.org/10.1109/EIT.2017.8053442

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abstract = "We expressed the importance of frequency characteristics of T-type calcium signaling in every level of the nervous system. We also highlighted the need for performing frequency analysis on calcium signals in order to understand their impact on various functions within the nervous system. We provided the necessary analytical and computational frameworks for doing power spectral density (PSD) analysis of calcium T-type signals. For this purpose, we modeled a calcium T-type channel gating mechanism using a Markov scheme and formulated the calcium ionic current with the help of some empirical data. Our analysis shows calcium T-type current fades out rapidly at an exponential rate when frequency is increased but decreases almost linearly with depolarization of the membrane.",

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N2 - We expressed the importance of frequency characteristics of T-type calcium signaling in every level of the nervous system. We also highlighted the need for performing frequency analysis on calcium signals in order to understand their impact on various functions within the nervous system. We provided the necessary analytical and computational frameworks for doing power spectral density (PSD) analysis of calcium T-type signals. For this purpose, we modeled a calcium T-type channel gating mechanism using a Markov scheme and formulated the calcium ionic current with the help of some empirical data. Our analysis shows calcium T-type current fades out rapidly at an exponential rate when frequency is increased but decreases almost linearly with depolarization of the membrane.

AB - We expressed the importance of frequency characteristics of T-type calcium signaling in every level of the nervous system. We also highlighted the need for performing frequency analysis on calcium signals in order to understand their impact on various functions within the nervous system. We provided the necessary analytical and computational frameworks for doing power spectral density (PSD) analysis of calcium T-type signals. For this purpose, we modeled a calcium T-type channel gating mechanism using a Markov scheme and formulated the calcium ionic current with the help of some empirical data. Our analysis shows calcium T-type current fades out rapidly at an exponential rate when frequency is increased but decreases almost linearly with depolarization of the membrane.

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A frequency analysis on calcium T-type signaling in the nervous system

Abstract

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Keywords

ASJC Scopus subject areas

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