A frequency analysis on calcium T-type signaling in the nervous system

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

We expressed the importance of frequency characteristics of T-type calcium signaling in every level of the nervous system. We also highlighted the need for performing frequency analysis on calcium signals in order to understand their impact on various functions within the nervous system. We provided the necessary analytical and computational frameworks for doing power spectral density (PSD) analysis of calcium T-type signals. For this purpose, we modeled a calcium T-type channel gating mechanism using a Markov scheme and formulated the calcium ionic current with the help of some empirical data. Our analysis shows calcium T-type current fades out rapidly at an exponential rate when frequency is increased but decreases almost linearly with depolarization of the membrane.

Original languageEnglish (US)
Title of host publication2017 IEEE International Conference on Electro Information Technology, EIT 2017
PublisherIEEE Computer Society
Pages640-644
Number of pages5
ISBN (Electronic)9781509047673
DOIs
StatePublished - Sep 27 2017
Event2017 IEEE International Conference on Electro Information Technology, EIT 2017 - Lincoln, United States
Duration: May 14 2017May 17 2017

Publication series

NameIEEE International Conference on Electro Information Technology
ISSN (Print)2154-0357
ISSN (Electronic)2154-0373

Other

Other2017 IEEE International Conference on Electro Information Technology, EIT 2017
CountryUnited States
CityLincoln
Period5/14/175/17/17

Keywords

  • Calcium Markov Process
  • Calcium Monte Carlo Simulation
  • Calcium Signaling
  • Calcium T-type Channels
  • Frequency Analysis
  • Neurons
  • Power Spectral Density

ASJC Scopus subject areas

  • Computer Science Applications
  • Information Systems
  • Control and Systems Engineering
  • Electrical and Electronic Engineering

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  • Cite this

    Khodaei, A., Vakilzadian, H., & Pierobon, M. (2017). A frequency analysis on calcium T-type signaling in the nervous system. In 2017 IEEE International Conference on Electro Information Technology, EIT 2017 (pp. 640-644). [8053442] (IEEE International Conference on Electro Information Technology). IEEE Computer Society. https://doi.org/10.1109/EIT.2017.8053442