A genome-wide linkage scan for quantitative trait loci underlying obesity related phenotypes in 434 Caucasian families

Lan Juan Zhao, Peng Xiao, Yong Jun Liu, Dong Hai Xiong, Hui Shen, Robert R. Recker, Hong Wen Deng

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Abstract

To identify quantitative trait loci (QTLs) that contribute to obesity, we performed a large-scale whole genome linkage scan (WGS) involving 4,102 individuals from 434 Caucasian families. The most pronounced linkage evidence was found at the genomic region 20p11-12 for fat mass (LOD = 3.31) and percentage fat mass (PFM) (LOD = 2.92). We also identified several regions showing suggestive linkage signals (threshold LOD = 1.9) for obesity phenotypes, including 5q35, 8q13, 10p12, and 17q11.

Original languageEnglish (US)
Pages (from-to)145-148
Number of pages4
JournalHuman genetics
Volume121
Issue number1
DOIs
StatePublished - Mar 1 2007

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ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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