A group M consensus envelope glycoprotein induces antibodies that neutralize subsets of subtype B and C HIV-1 primary viruses

Hua Xin Liao, Laura L. Sutherland, Shi Mao Xia, Mary E. Brock, Richard M. Scearce, Stacie Vanleeuwen, S. Munir Alam, Mildred McAdams, Eric A. Weaver, Zenaido T. Camacho, Ben Jiang Ma, Yingying Li, Julie M. Decker, Gary J. Nabel, David C. Montefiori, Beatrice H. Hahn, Bette T. Korber, Feng Gao, Barton F. Haynes

Research output: Contribution to journalArticle

154 Scopus citations

Abstract

HIV-1 subtype C is the most common HIV-1 group M subtype in Africa and many parts of Asia. However, to date HIV-1 vaccine candidate immunogens have not induced potent and broadly neutralizing antibodies against subtype C primary isolates. We have used a centralized gene strategy to address HIV-1 diversity and generated a group M consensus envelope gene with shortened consensus variable loops (CON-S) for comparative studies with wild-type (WT) Env immunogens. Our results indicate that the consensus HIV-1 group M CON-S Env elicited cross-subtype neutralizing antibodies of similar or greater breadth and titer than the WT Envs tested, indicating the utility of a centralized gene strategy. Our study also shows the feasibility of iterative improvements in Env immunogenicity by rational design of centralized genes.

Original languageEnglish (US)
Pages (from-to)268-282
Number of pages15
JournalVirology
Volume353
Issue number2
DOIs
StatePublished - Sep 30 2006

Keywords

  • Consensus immunogens
  • HIV-1
  • Neutralization antibody
  • Vaccine

ASJC Scopus subject areas

  • Virology

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    Liao, H. X., Sutherland, L. L., Xia, S. M., Brock, M. E., Scearce, R. M., Vanleeuwen, S., Alam, S. M., McAdams, M., Weaver, E. A., Camacho, Z. T., Ma, B. J., Li, Y., Decker, J. M., Nabel, G. J., Montefiori, D. C., Hahn, B. H., Korber, B. T., Gao, F., & Haynes, B. F. (2006). A group M consensus envelope glycoprotein induces antibodies that neutralize subsets of subtype B and C HIV-1 primary viruses. Virology, 353(2), 268-282. https://doi.org/10.1016/j.virol.2006.04.043