Abstract
We report the design and fabrication of a DNA-based electrochemical sensor for detection of glutathione. Sensor signaling relies on glutathione's ability to chelate mercury Hg(II), displacing it from the thymine–Hg(II)–thymine complex formed between the surface-immobilized DNA probes. Our results show that this sensor is sensitive and selective enough to be employed in saliva.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 8385-8387 |
| Number of pages | 3 |
| Journal | Chemical Communications |
| Volume | 50 |
| Issue number | 61 |
| DOIs | |
| State | Published - Jul 3 2014 |
ASJC Scopus subject areas
- Catalysis
- Electronic, Optical and Magnetic Materials
- Ceramics and Composites
- Chemistry(all)
- Surfaces, Coatings and Films
- Metals and Alloys
- Materials Chemistry
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Zhad, H. R. L. Z., & Lai, R. Y. (2014). A hg(ii)-mediated “signal-on” electrochemical glutathione sensor. Chemical Communications, 50(61), 8385-8387. https://doi.org/10.1039/c4cc03329a