A hg(ii)-mediated “signal-on” electrochemical glutathione sensor

Hamid R.Lotfi Zadeh Zhad; Rebecca Y. Lai

doi:10.1039/c4cc03329a

A hg(ii)-mediated “signal-on” electrochemical glutathione sensor

Hamid R.Lotfi Zadeh Zhad, Rebecca Y. Lai

Chemistry

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

We report the design and fabrication of a DNA-based electrochemical sensor for detection of glutathione. Sensor signaling relies on glutathione's ability to chelate mercury Hg(II), displacing it from the thymine–Hg(II)–thymine complex formed between the surface-immobilized DNA probes. Our results show that this sensor is sensitive and selective enough to be employed in saliva.

Original language	English (US)
Pages (from-to)	8385-8387
Number of pages	3
Journal	Chemical Communications
Volume	50
Issue number	61
DOIs	https://doi.org/10.1039/c4cc03329a
State	Published - Jul 3 2014

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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AB - We report the design and fabrication of a DNA-based electrochemical sensor for detection of glutathione. Sensor signaling relies on glutathione's ability to chelate mercury Hg(II), displacing it from the thymine–Hg(II)–thymine complex formed between the surface-immobilized DNA probes. Our results show that this sensor is sensitive and selective enough to be employed in saliva.

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A hg(ii)-mediated “signal-on” electrochemical glutathione sensor

Abstract

ASJC Scopus subject areas

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