A hg(ii)-mediated “signal-on” electrochemical glutathione sensor

Hamid R.Lotfi Zadeh Zhad, Rebecca Y. Lai

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

We report the design and fabrication of a DNA-based electrochemical sensor for detection of glutathione. Sensor signaling relies on glutathione's ability to chelate mercury Hg(II), displacing it from the thymine–Hg(II)–thymine complex formed between the surface-immobilized DNA probes. Our results show that this sensor is sensitive and selective enough to be employed in saliva.

Original languageEnglish (US)
Pages (from-to)8385-8387
Number of pages3
JournalChemical Communications
Volume50
Issue number61
DOIs
StatePublished - Jul 3 2014

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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