A hg(ii)-mediated “signal-on” electrochemical glutathione sensor

Hamid R.Lotfi Zadeh Zhad; Rebecca Y. Lai

doi:10.1039/c4cc03329a

A hg(ii)-mediated “signal-on” electrochemical glutathione sensor

Hamid R.Lotfi Zadeh Zhad, Rebecca Y. Lai

Chemistry

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

We report the design and fabrication of a DNA-based electrochemical sensor for detection of glutathione. Sensor signaling relies on glutathione's ability to chelate mercury Hg(II), displacing it from the thymine–Hg(II)–thymine complex formed between the surface-immobilized DNA probes. Our results show that this sensor is sensitive and selective enough to be employed in saliva.

Original language	English (US)
Pages (from-to)	8385-8387
Number of pages	3
Journal	Chemical Communications
Volume	50
Issue number	61
DOIs	https://doi.org/10.1039/c4cc03329a
State	Published - Jul 3 2014

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

Access to Document

10.1039/c4cc03329a

Cite this

@article{e57ef155f1df4a7c8525d4363cea057d,

title = "A hg(ii)-mediated “signal-on” electrochemical glutathione sensor",

abstract = "We report the design and fabrication of a DNA-based electrochemical sensor for detection of glutathione. Sensor signaling relies on glutathione's ability to chelate mercury Hg(II), displacing it from the thymine–Hg(II)–thymine complex formed between the surface-immobilized DNA probes. Our results show that this sensor is sensitive and selective enough to be employed in saliva.",

author = "Zhad, {Hamid R.Lotfi Zadeh} and Lai, {Rebecca Y.}",

year = "2014",

month = jul,

day = "3",

doi = "10.1039/c4cc03329a",

language = "English (US)",

volume = "50",

pages = "8385--8387",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "61",

}

TY - JOUR

T1 - A hg(ii)-mediated “signal-on” electrochemical glutathione sensor

AU - Zhad, Hamid R.Lotfi Zadeh

AU - Lai, Rebecca Y.

PY - 2014/7/3

Y1 - 2014/7/3

N2 - We report the design and fabrication of a DNA-based electrochemical sensor for detection of glutathione. Sensor signaling relies on glutathione's ability to chelate mercury Hg(II), displacing it from the thymine–Hg(II)–thymine complex formed between the surface-immobilized DNA probes. Our results show that this sensor is sensitive and selective enough to be employed in saliva.

AB - We report the design and fabrication of a DNA-based electrochemical sensor for detection of glutathione. Sensor signaling relies on glutathione's ability to chelate mercury Hg(II), displacing it from the thymine–Hg(II)–thymine complex formed between the surface-immobilized DNA probes. Our results show that this sensor is sensitive and selective enough to be employed in saliva.

UR - http://www.scopus.com/inward/record.url?scp=84903975988&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84903975988&partnerID=8YFLogxK

U2 - 10.1039/c4cc03329a

DO - 10.1039/c4cc03329a

M3 - Article

C2 - 24942852

AN - SCOPUS:84903975988

VL - 50

SP - 8385

EP - 8387

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

IS - 61

ER -

A hg(ii)-mediated “signal-on” electrochemical glutathione sensor

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this