A highly conserved family of inactivated archaeal B family DNA polymerases

Igor B. Rogozin, Kira S. Makarova, Youri I. Pavlov, Eugene V. Koonin

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


A widespread and highly conserved family of apparently inactivated derivatives of archaeal B-family DNA polymerases is described. Phylogenetic analysis shows that the inactivated forms comprise a distinct clade among archaeal B-family polymerases and that, within this clade, Euryarchaea and Crenarchaea are clearly separated from each other and from a small group of bacterial homologs. These findings are compatible with an ancient duplication of the DNA polymerase gene followed by inactivation and parallel loss in some of the lineages although contribution of horizontal gene transfer cannot be ruled out. The inactivated derivative of the archaeal DNA polymerase could form a complex with the active paralog and play a structural role in DNA replication.

Original languageEnglish (US)
Article number32
JournalBiology direct
StatePublished - Aug 6 2008

ASJC Scopus subject areas

  • Immunology
  • Ecology, Evolution, Behavior and Systematics
  • Modeling and Simulation
  • General Biochemistry, Genetics and Molecular Biology
  • General Agricultural and Biological Sciences
  • Applied Mathematics


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