A highly selective pyrene based fluorescent sensor toward Hg2+ detection

Yang Yang; Xiaojun Gou; John Blecha; Haishi Cao

doi:10.1016/j.tetlet.2010.04.100

A highly selective pyrene based fluorescent sensor toward Hg²⁺ detection

Yang Yang, Xiaojun Gou, John Blecha, Haishi Cao

Chemistry

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

Abstract

A new pyrene-containing fluorescent sensor has been synthesized from 2,3,3-trimethylindolenine. Spectroscopic and photophysical properties of sensor are presented. The large change in fluorescence intensity (I/I₀ = 0.13) at 381 nm and affinity to Hg²⁺ over other cations such as K⁺, Na⁺, Ca²⁺, Mg²⁺, Pb²⁺, and Cu²⁺ make this compound a useful chemosensor for Hg²⁺ detection in hydrophilic media. The sensor (6.0 × 10^-6 M) displays significant fluorescence quenching upon addition of Hg²⁺ in pH 7.4 HEPES buffer without excimer formation. Job's plot analysis shows the binding stoichiometry to be 2:1 (host/guest).

Original language	English (US)
Pages (from-to)	3422-3425
Number of pages	4
Journal	Tetrahedron Letters
Volume	51
Issue number	26
DOIs	https://doi.org/10.1016/j.tetlet.2010.04.100
State	Published - Jun 30 2010

Keywords

Fluorescent sensor
Hg
Pyrene

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

Access to Document

10.1016/j.tetlet.2010.04.100

Cite this

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title = "A highly selective pyrene based fluorescent sensor toward Hg2+ detection",

abstract = "A new pyrene-containing fluorescent sensor has been synthesized from 2,3,3-trimethylindolenine. Spectroscopic and photophysical properties of sensor are presented. The large change in fluorescence intensity (I/I0 = 0.13) at 381 nm and affinity to Hg2+ over other cations such as K+, Na+, Ca2+, Mg2+, Pb2+, and Cu2+ make this compound a useful chemosensor for Hg2+ detection in hydrophilic media. The sensor (6.0 × 10-6 M) displays significant fluorescence quenching upon addition of Hg2+ in pH 7.4 HEPES buffer without excimer formation. Job's plot analysis shows the binding stoichiometry to be 2:1 (host/guest).",

keywords = "Fluorescent sensor, Hg, Pyrene",

author = "Yang Yang and Xiaojun Gou and John Blecha and Haishi Cao",

note = "Funding Information: This research is supported by the University of Nebraska at Kearney{\textquoteright}s University Research and Creative Activity fund , Undergraduate Fellows Research Program , and Summer Student Research Program . Authors would also like to acknowledge Dr. Michael D. Mosher for his assistance in collecting NMR spectra. ",

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doi = "10.1016/j.tetlet.2010.04.100",

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T1 - A highly selective pyrene based fluorescent sensor toward Hg2+ detection

AU - Yang, Yang

AU - Gou, Xiaojun

AU - Blecha, John

AU - Cao, Haishi

N1 - Funding Information: This research is supported by the University of Nebraska at Kearney’s University Research and Creative Activity fund , Undergraduate Fellows Research Program , and Summer Student Research Program . Authors would also like to acknowledge Dr. Michael D. Mosher for his assistance in collecting NMR spectra.

PY - 2010/6/30

Y1 - 2010/6/30

N2 - A new pyrene-containing fluorescent sensor has been synthesized from 2,3,3-trimethylindolenine. Spectroscopic and photophysical properties of sensor are presented. The large change in fluorescence intensity (I/I0 = 0.13) at 381 nm and affinity to Hg2+ over other cations such as K+, Na+, Ca2+, Mg2+, Pb2+, and Cu2+ make this compound a useful chemosensor for Hg2+ detection in hydrophilic media. The sensor (6.0 × 10-6 M) displays significant fluorescence quenching upon addition of Hg2+ in pH 7.4 HEPES buffer without excimer formation. Job's plot analysis shows the binding stoichiometry to be 2:1 (host/guest).

AB - A new pyrene-containing fluorescent sensor has been synthesized from 2,3,3-trimethylindolenine. Spectroscopic and photophysical properties of sensor are presented. The large change in fluorescence intensity (I/I0 = 0.13) at 381 nm and affinity to Hg2+ over other cations such as K+, Na+, Ca2+, Mg2+, Pb2+, and Cu2+ make this compound a useful chemosensor for Hg2+ detection in hydrophilic media. The sensor (6.0 × 10-6 M) displays significant fluorescence quenching upon addition of Hg2+ in pH 7.4 HEPES buffer without excimer formation. Job's plot analysis shows the binding stoichiometry to be 2:1 (host/guest).

KW - Fluorescent sensor

KW - Hg

KW - Pyrene

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