A highly selective pyrene based fluorescent sensor toward Hg2+ detection

Yang Yang, Xiaojun Gou, John Blecha, Haishi Cao

Research output: Contribution to journalArticlepeer-review

60 Scopus citations


A new pyrene-containing fluorescent sensor has been synthesized from 2,3,3-trimethylindolenine. Spectroscopic and photophysical properties of sensor are presented. The large change in fluorescence intensity (I/I0 = 0.13) at 381 nm and affinity to Hg2+ over other cations such as K+, Na+, Ca2+, Mg2+, Pb2+, and Cu2+ make this compound a useful chemosensor for Hg2+ detection in hydrophilic media. The sensor (6.0 × 10-6 M) displays significant fluorescence quenching upon addition of Hg2+ in pH 7.4 HEPES buffer without excimer formation. Job's plot analysis shows the binding stoichiometry to be 2:1 (host/guest).

Original languageEnglish (US)
Pages (from-to)3422-3425
Number of pages4
JournalTetrahedron Letters
Issue number26
StatePublished - Jun 30 2010


  • Fluorescent sensor
  • Hg
  • Pyrene

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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