A highly selective pyrene based fluorescent sensor toward Hg2+ detection

Yang Yang; Xiaojun Gou; John Blecha; Haishi Cao

doi:10.1016/j.tetlet.2010.04.100

A highly selective pyrene based fluorescent sensor toward Hg²⁺ detection

Yang Yang, Xiaojun Gou, John Blecha, Haishi Cao

Chemistry

Research output: Contribution to journal › Article › peer-review

63 Scopus citations

Abstract

A new pyrene-containing fluorescent sensor has been synthesized from 2,3,3-trimethylindolenine. Spectroscopic and photophysical properties of sensor are presented. The large change in fluorescence intensity (I/I₀ = 0.13) at 381 nm and affinity to Hg²⁺ over other cations such as K⁺, Na⁺, Ca²⁺, Mg²⁺, Pb²⁺, and Cu²⁺ make this compound a useful chemosensor for Hg²⁺ detection in hydrophilic media. The sensor (6.0 × 10^-6 M) displays significant fluorescence quenching upon addition of Hg²⁺ in pH 7.4 HEPES buffer without excimer formation. Job's plot analysis shows the binding stoichiometry to be 2:1 (host/guest).

Original language	English (US)
Pages (from-to)	3422-3425
Number of pages	4
Journal	Tetrahedron Letters
Volume	51
Issue number	26
DOIs	https://doi.org/10.1016/j.tetlet.2010.04.100
State	Published - Jun 30 2010

Keywords

Fluorescent sensor
Hg
Pyrene

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

Access to Document

10.1016/j.tetlet.2010.04.100

Cite this

@article{657cffb51d10486d857203f862a9f1aa,

title = "A highly selective pyrene based fluorescent sensor toward Hg2+ detection",

abstract = "A new pyrene-containing fluorescent sensor has been synthesized from 2,3,3-trimethylindolenine. Spectroscopic and photophysical properties of sensor are presented. The large change in fluorescence intensity (I/I0 = 0.13) at 381 nm and affinity to Hg2+ over other cations such as K+, Na+, Ca2+, Mg2+, Pb2+, and Cu2+ make this compound a useful chemosensor for Hg2+ detection in hydrophilic media. The sensor (6.0 × 10-6 M) displays significant fluorescence quenching upon addition of Hg2+ in pH 7.4 HEPES buffer without excimer formation. Job's plot analysis shows the binding stoichiometry to be 2:1 (host/guest).",

keywords = "Fluorescent sensor, Hg, Pyrene",

author = "Yang Yang and Xiaojun Gou and John Blecha and Haishi Cao",

note = "Funding Information: This research is supported by the University of Nebraska at Kearney{\textquoteright}s University Research and Creative Activity fund , Undergraduate Fellows Research Program , and Summer Student Research Program . Authors would also like to acknowledge Dr. Michael D. Mosher for his assistance in collecting NMR spectra. ",

year = "2010",

month = jun,

day = "30",

doi = "10.1016/j.tetlet.2010.04.100",

language = "English (US)",

volume = "51",

pages = "3422--3425",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Ltd",

number = "26",

}

TY - JOUR

T1 - A highly selective pyrene based fluorescent sensor toward Hg2+ detection

AU - Yang, Yang

AU - Gou, Xiaojun

AU - Blecha, John

AU - Cao, Haishi

N1 - Funding Information: This research is supported by the University of Nebraska at Kearney’s University Research and Creative Activity fund , Undergraduate Fellows Research Program , and Summer Student Research Program . Authors would also like to acknowledge Dr. Michael D. Mosher for his assistance in collecting NMR spectra.

PY - 2010/6/30

Y1 - 2010/6/30

N2 - A new pyrene-containing fluorescent sensor has been synthesized from 2,3,3-trimethylindolenine. Spectroscopic and photophysical properties of sensor are presented. The large change in fluorescence intensity (I/I0 = 0.13) at 381 nm and affinity to Hg2+ over other cations such as K+, Na+, Ca2+, Mg2+, Pb2+, and Cu2+ make this compound a useful chemosensor for Hg2+ detection in hydrophilic media. The sensor (6.0 × 10-6 M) displays significant fluorescence quenching upon addition of Hg2+ in pH 7.4 HEPES buffer without excimer formation. Job's plot analysis shows the binding stoichiometry to be 2:1 (host/guest).

AB - A new pyrene-containing fluorescent sensor has been synthesized from 2,3,3-trimethylindolenine. Spectroscopic and photophysical properties of sensor are presented. The large change in fluorescence intensity (I/I0 = 0.13) at 381 nm and affinity to Hg2+ over other cations such as K+, Na+, Ca2+, Mg2+, Pb2+, and Cu2+ make this compound a useful chemosensor for Hg2+ detection in hydrophilic media. The sensor (6.0 × 10-6 M) displays significant fluorescence quenching upon addition of Hg2+ in pH 7.4 HEPES buffer without excimer formation. Job's plot analysis shows the binding stoichiometry to be 2:1 (host/guest).

KW - Fluorescent sensor

KW - Hg

KW - Pyrene

UR - http://www.scopus.com/inward/record.url?scp=77953120241&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77953120241&partnerID=8YFLogxK

U2 - 10.1016/j.tetlet.2010.04.100

DO - 10.1016/j.tetlet.2010.04.100

M3 - Article

AN - SCOPUS:77953120241

SN - 0040-4039

VL - 51

SP - 3422

EP - 3425

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 26

ER -