@article{59fc8b5ea20446a1b28618e765a3edbd,
title = "A Human Papillomavirus-Independent Cervical Cancer Animal Model Reveals Unconventional Mechanisms of Cervical Carcinogenesis",
abstract = "HPV infections are common in healthy women and only rarely cause cervical cancer. He et al. provide evidence that hyperactivation of the YAP1 oncogene can drive cervical cancer initiation and progression. YAP1 hyperactivation in cervical epithelial cells increases the HPV receptors and disrupts host cell innate immunity, facilitating HPV infection.",
keywords = "HPV infection, HPV receptor molecules, Hippo pathway, YAP1 oncogene, cervical cancer mouse model, cervical carcinogenesis, innate immunity, interferon-stimulated genes, molecular mechanism, type I interferon",
author = "Chunbo He and Xiangmin Lv and Cong Huang and Angeletti, {Peter C.} and Guohua Hua and Jixin Dong and Jin Zhou and Zhengfeng Wang and Bowen Ma and Xingcheng Chen and Lambert, {Paul F.} and Rueda, {Bo R.} and Davis, {John S.} and Cheng Wang",
note = "Funding Information: This work was supported by the National Cancer Institute (1R01CA197976 and 1R01CA201500); the Colleen's Dream Foundation; the Olson Center for Women's Health; the Fred & Pamela Buffett Cancer Center (LB595); the Marsha Rivkin Center for Cancer Research (the Barbara Learned Bridge Funding Award); the Vincent Memorial Hospital Foundation; and the Vincent Center for Reproductive Biology. Funding Information: This work was supported by the National Cancer Institute ( 1R01CA197976 and 1R01CA201500 ); the Colleen{\textquoteright}s Dream Foundation ; the Olson Center for Women{\textquoteright}s Health ; the Fred & Pamela Buffett Cancer Center ( LB595 ); the Marsha Rivkin Center for Cancer Research (the Barbara Learned Bridge Funding Award); the Vincent Memorial Hospital Foundation ; and the Vincent Center for Reproductive Biology . Publisher Copyright: {\textcopyright} 2019 The Author(s)",
year = "2019",
month = mar,
day = "5",
doi = "10.1016/j.celrep.2019.02.004",
language = "English (US)",
volume = "26",
pages = "2636--2650.e5",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "10",
}