A Human Papillomavirus-Independent Cervical Cancer Animal Model Reveals Unconventional Mechanisms of Cervical Carcinogenesis

Chunbo He, Xiangmin Lv, Cong Huang, Peter C. Angeletti, Guohua Hua, Jixin Dong, Jin Zhou, Zhengfeng Wang, Bowen Ma, Xingcheng Chen, Paul F. Lambert, Bo R. Rueda, John S. Davis, Cheng Wang

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

HPV infections are common in healthy women and only rarely cause cervical cancer. He et al. provide evidence that hyperactivation of the YAP1 oncogene can drive cervical cancer initiation and progression. YAP1 hyperactivation in cervical epithelial cells increases the HPV receptors and disrupts host cell innate immunity, facilitating HPV infection.

Original languageEnglish (US)
Pages (from-to)2636-2650.e5
JournalCell Reports
Volume26
Issue number10
DOIs
StatePublished - Mar 5 2019

Keywords

  • HPV infection
  • HPV receptor molecules
  • Hippo pathway
  • YAP1 oncogene
  • cervical cancer mouse model
  • cervical carcinogenesis
  • innate immunity
  • interferon-stimulated genes
  • molecular mechanism
  • type I interferon

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    He, C., Lv, X., Huang, C., Angeletti, P. C., Hua, G., Dong, J., Zhou, J., Wang, Z., Ma, B., Chen, X., Lambert, P. F., Rueda, B. R., Davis, J. S., & Wang, C. (2019). A Human Papillomavirus-Independent Cervical Cancer Animal Model Reveals Unconventional Mechanisms of Cervical Carcinogenesis. Cell Reports, 26(10), 2636-2650.e5. https://doi.org/10.1016/j.celrep.2019.02.004