A Human Papillomavirus-Independent Cervical Cancer Animal Model Reveals Unconventional Mechanisms of Cervical Carcinogenesis

Chunbo He; Xiangmin Lv; Cong Huang; Peter C. Angeletti; Guohua Hua; Jixin Dong; Jin Zhou; Zhengfeng Wang; Bowen Ma; Xingcheng Chen; Paul F. Lambert; Bo R. Rueda; John S. Davis; Cheng Wang

doi:10.1016/j.celrep.2019.02.004

A Human Papillomavirus-Independent Cervical Cancer Animal Model Reveals Unconventional Mechanisms of Cervical Carcinogenesis

Chunbo He, Xiangmin Lv, Cong Huang, Peter C. Angeletti, Guohua Hua, Jixin Dong, Jin Zhou, Zhengfeng Wang, Bowen Ma, Xingcheng Chen, Paul F. Lambert, Bo R. Rueda, John S. Davis, Cheng Wang

Research output: Contribution to journal › Article

8 Scopus citations

Abstract

HPV infections are common in healthy women and only rarely cause cervical cancer. He et al. provide evidence that hyperactivation of the YAP1 oncogene can drive cervical cancer initiation and progression. YAP1 hyperactivation in cervical epithelial cells increases the HPV receptors and disrupts host cell innate immunity, facilitating HPV infection.

Original language	English (US)
Pages (from-to)	2636-2650.e5
Journal	Cell Reports
Volume	26
Issue number	10
DOIs	https://doi.org/10.1016/j.celrep.2019.02.004
State	Published - Mar 5 2019

Keywords

HPV infection
HPV receptor molecules
Hippo pathway
YAP1 oncogene
cervical cancer mouse model
cervical carcinogenesis
innate immunity
interferon-stimulated genes
molecular mechanism
type I interferon

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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He, C., Lv, X., Huang, C., Angeletti, P. C., Hua, G., Dong, J., Zhou, J., Wang, Z., Ma, B., Chen, X., Lambert, P. F., Rueda, B. R., Davis, J. S., & Wang, C. (2019). A Human Papillomavirus-Independent Cervical Cancer Animal Model Reveals Unconventional Mechanisms of Cervical Carcinogenesis. Cell Reports, 26(10), 2636-2650.e5. https://doi.org/10.1016/j.celrep.2019.02.004

A Human Papillomavirus-Independent Cervical Cancer Animal Model Reveals Unconventional Mechanisms of Cervical Carcinogenesis. / He, Chunbo; Lv, Xiangmin; Huang, Cong; Angeletti, Peter C.; Hua, Guohua; Dong, Jixin; Zhou, Jin; Wang, Zhengfeng; Ma, Bowen; Chen, Xingcheng; Lambert, Paul F.; Rueda, Bo R.; Davis, John S.; Wang, Cheng.

In: Cell Reports, Vol. 26, No. 10, 05.03.2019, p. 2636-2650.e5.

Research output: Contribution to journal › Article

He, Chunbo ; Lv, Xiangmin ; Huang, Cong ; Angeletti, Peter C. ; Hua, Guohua ; Dong, Jixin ; Zhou, Jin ; Wang, Zhengfeng ; Ma, Bowen ; Chen, Xingcheng ; Lambert, Paul F. ; Rueda, Bo R. ; Davis, John S. ; Wang, Cheng. / A Human Papillomavirus-Independent Cervical Cancer Animal Model Reveals Unconventional Mechanisms of Cervical Carcinogenesis. In: Cell Reports. 2019 ; Vol. 26, No. 10. pp. 2636-2650.e5.

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abstract = "HPV infections are common in healthy women and only rarely cause cervical cancer. He et al. provide evidence that hyperactivation of the YAP1 oncogene can drive cervical cancer initiation and progression. YAP1 hyperactivation in cervical epithelial cells increases the HPV receptors and disrupts host cell innate immunity, facilitating HPV infection.",

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