A Human Papillomavirus-Independent Cervical Cancer Animal Model Reveals Unconventional Mechanisms of Cervical Carcinogenesis

Chunbo He; Xiangmin Lv; Cong Huang; Peter C. Angeletti; Guohua Hua; Jixin Dong; Jin Zhou; Zhengfeng Wang; Bowen Ma; Xingcheng Chen; Paul F. Lambert; Bo R. Rueda; John S. Davis; Cheng Wang

doi:10.1016/j.celrep.2019.02.004

A Human Papillomavirus-Independent Cervical Cancer Animal Model Reveals Unconventional Mechanisms of Cervical Carcinogenesis

Chunbo He, Xiangmin Lv, Cong Huang, Peter C. Angeletti, Guohua Hua, Jixin Dong, Jin Zhou, Zhengfeng Wang, Bowen Ma, Xingcheng Chen, Paul F. Lambert, Bo R. Rueda, John S. Davis, Cheng Wang

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

HPV infections are common in healthy women and only rarely cause cervical cancer. He et al. provide evidence that hyperactivation of the YAP1 oncogene can drive cervical cancer initiation and progression. YAP1 hyperactivation in cervical epithelial cells increases the HPV receptors and disrupts host cell innate immunity, facilitating HPV infection.

Original language	English (US)
Pages (from-to)	2636-2650.e5
Journal	Cell Reports
Volume	26
Issue number	10
DOIs	https://doi.org/10.1016/j.celrep.2019.02.004
State	Published - Mar 5 2019

Keywords

HPV infection
HPV receptor molecules
Hippo pathway
YAP1 oncogene
cervical cancer mouse model
cervical carcinogenesis
innate immunity
interferon-stimulated genes
molecular mechanism
type I interferon

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.celrep.2019.02.004

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He, C., Lv, X., Huang, C., Angeletti, P. C., Hua, G., Dong, J., Zhou, J., Wang, Z., Ma, B., Chen, X., Lambert, P. F., Rueda, B. R., Davis, J. S., & Wang, C. (2019). A Human Papillomavirus-Independent Cervical Cancer Animal Model Reveals Unconventional Mechanisms of Cervical Carcinogenesis. Cell Reports, 26(10), 2636-2650.e5. https://doi.org/10.1016/j.celrep.2019.02.004

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title = "A Human Papillomavirus-Independent Cervical Cancer Animal Model Reveals Unconventional Mechanisms of Cervical Carcinogenesis",

abstract = "HPV infections are common in healthy women and only rarely cause cervical cancer. He et al. provide evidence that hyperactivation of the YAP1 oncogene can drive cervical cancer initiation and progression. YAP1 hyperactivation in cervical epithelial cells increases the HPV receptors and disrupts host cell innate immunity, facilitating HPV infection.",

keywords = "HPV infection, HPV receptor molecules, Hippo pathway, YAP1 oncogene, cervical cancer mouse model, cervical carcinogenesis, innate immunity, interferon-stimulated genes, molecular mechanism, type I interferon",

author = "Chunbo He and Xiangmin Lv and Cong Huang and Angeletti, {Peter C.} and Guohua Hua and Jixin Dong and Jin Zhou and Zhengfeng Wang and Bowen Ma and Xingcheng Chen and Lambert, {Paul F.} and Rueda, {Bo R.} and Davis, {John S.} and Cheng Wang",

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doi = "10.1016/j.celrep.2019.02.004",

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T1 - A Human Papillomavirus-Independent Cervical Cancer Animal Model Reveals Unconventional Mechanisms of Cervical Carcinogenesis

AU - He, Chunbo

AU - Lv, Xiangmin

AU - Huang, Cong

AU - Angeletti, Peter C.

AU - Hua, Guohua

AU - Dong, Jixin

AU - Zhou, Jin

AU - Wang, Zhengfeng

AU - Ma, Bowen

AU - Chen, Xingcheng

AU - Lambert, Paul F.

AU - Rueda, Bo R.

AU - Davis, John S.

AU - Wang, Cheng

PY - 2019/3/5

Y1 - 2019/3/5

N2 - HPV infections are common in healthy women and only rarely cause cervical cancer. He et al. provide evidence that hyperactivation of the YAP1 oncogene can drive cervical cancer initiation and progression. YAP1 hyperactivation in cervical epithelial cells increases the HPV receptors and disrupts host cell innate immunity, facilitating HPV infection.

AB - HPV infections are common in healthy women and only rarely cause cervical cancer. He et al. provide evidence that hyperactivation of the YAP1 oncogene can drive cervical cancer initiation and progression. YAP1 hyperactivation in cervical epithelial cells increases the HPV receptors and disrupts host cell innate immunity, facilitating HPV infection.

KW - HPV infection

KW - HPV receptor molecules

KW - Hippo pathway

KW - YAP1 oncogene

KW - cervical cancer mouse model

KW - cervical carcinogenesis

KW - innate immunity

KW - interferon-stimulated genes

KW - molecular mechanism

KW - type I interferon

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JF - Cell Reports

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A Human Papillomavirus-Independent Cervical Cancer Animal Model Reveals Unconventional Mechanisms of Cervical Carcinogenesis

Abstract

Keywords

ASJC Scopus subject areas

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