A hybrid PDMS/paper passive pump for slow-release/delivery of drugs in chronic dermal wounds

Rahim Rahimi, Manuel Ochoa, Jiawei Zhou, Ali Tamayol, Mehmet R. Dokmeci, Ali Khademhosseini, Amir Ghaemmaghami, Babak Ziaie

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In this paper, we present a hybrid PDMS/paper-based passive pump for slow drug delivery in chronic wounds. The pump consists of a PDMS microfluidic network that is irreversibly bonded to the polyethylene-coated (hydrophobic) side of a commercially-available freezer paper. The opposite (hygroscopic/hydrophilic) side of the freezer paper is connected to the PDMS microchannels to provide wicking-induced flow for slow drug delivery to the wound bed. The pump is characterized with various microchannel widths and liquid viscosities (i.e., by dissolving PVP in the drug). The results show that at higher viscosities the pump can achieve flow rates as small as 0.4 μl/min.

Original languageEnglish (US)
Title of host publication18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
PublisherChemical and Biological Microsystems Society
Pages2205-2207
Number of pages3
ISBN (Electronic)9780979806476
StatePublished - 2014
Event18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 - San Antonio, United States
Duration: Oct 26 2014Oct 30 2014

Publication series

Name18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014

Other

Other18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
CountryUnited States
CitySan Antonio
Period10/26/1410/30/14

Keywords

  • Capillary force
  • Chronic wound
  • Drug delivery
  • Paper
  • Pump

ASJC Scopus subject areas

  • Control and Systems Engineering

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  • Cite this

    Rahimi, R., Ochoa, M., Zhou, J., Tamayol, A., Dokmeci, M. R., Khademhosseini, A., Ghaemmaghami, A., & Ziaie, B. (2014). A hybrid PDMS/paper passive pump for slow-release/delivery of drugs in chronic dermal wounds. In 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 (pp. 2205-2207). (18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014). Chemical and Biological Microsystems Society.