A key role for ICAM-I in generating effector cells mediating inflammatory responses

Stephanie A. Camacho, William R. Heath, Francis R. Carbone, Nora Sarvetnick, Agnes LeBon, Lars Karlsson, Per A. Peterson, Susan R. Webb

Research output: Contribution to journalArticlepeer-review

72 Scopus citations


We investigated how the accessory molecule interactions encountered during T cell priming influence T cell-mediated destruction of insulin-producing β cells and lead to type I diabetes. T cell receptor (TCR)-transgenic CD4+ T cells were primed under controlled conditions in vitro before being adoptively transferred into transgenic recipients expressing membrane ovalbumin under the control of the rat insulin promoter (RIP-mOVA). During priming, antigen-presenting cell expression of B7-1 without intracellular adhesion molecule I (ICAM-1) led to the generation of effector cells that migrated to the pancreata of RIP-mOVA recipients but did not cause diabetes. In contrast, when T cells were primed with APCs expressing both B7-1 and ICAM-1, pronounced destruction of β cells and a rapid onset of diabetes were observed. Pathogenicity was associated with T cell production of the macrophage-attracting chemokines CCL3 and CCL4. Thus, interactions of lymphocyte function-associated antigen I with ICAM-1 during priming induce both qualitative and quantitative alterations in T effector function and induce potentially autodestructive responses.

Original languageEnglish (US)
Pages (from-to)523-529
Number of pages7
JournalNature Immunology
Issue number6
StatePublished - Jun 2001
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


Dive into the research topics of 'A key role for ICAM-I in generating effector cells mediating inflammatory responses'. Together they form a unique fingerprint.

Cite this