A literature review of the evidence that a 12% improvement in FEV1 is an appropriate cut-off for children

Rubell J. Hopp, Muhammad A. Pasha

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations


Introduction: A well-performed spirometry, using a change in forced expiratory volume in one second (FEV1) after albuterol, is commonly used to support the likelihood of an asthma diagnosis. The current standard, accepted by the 2007 National Heart Lung and Blood Institute Asthma Expert Panel Report-3 (EPR-3) guidelines, is a 12% improvement in the FEV1 after a bronchodilator. Objective: We sought to determine whether existing studies support or refute using a 12% improvement as a significant change in FEV1 in children and adolescents. Data sources: We reviewed the literature of children and adolescents using Medline searches to discover pertinent population studies and comparative studies that included FEV1 measurements. Result: The majority of the discovered studies suggest a leb stringent improvement in FEV1 in children might be applicable. Conclusion: Supported by the published literature, we suggest an alternative interpretive strategy of exprebing the results of a spirometry measurement when a diagnosis of asthma in a child is being considered using a bronchodilator response.

Original languageEnglish (US)
Pages (from-to)413-418
Number of pages6
JournalJournal of Asthma
Issue number4
StatePublished - Apr 20 2016
Externally publishedYes


  • Asthma
  • FEV1
  • bronchodilator response
  • bronchodilator tests
  • children
  • healthy controls
  • non-Asthmatic

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Immunology and Allergy
  • Pulmonary and Respiratory Medicine


Dive into the research topics of 'A literature review of the evidence that a 12% improvement in FEV1 is an appropriate cut-off for children'. Together they form a unique fingerprint.

Cite this