A manual-based intervention to address clinical crises and retain patients in the Treatment of Adolescents with Depression Study (TADS)

Diane E. May, Christopher J. Kratochvil, Susan E. Puumala, Susan G. Silva, Amy J. Rezac, Mary J. Hallin, Mark A. Reinecke, Benedetto Vitiello, Elizabeth B. Weller, Sanjeev Pathak, Anne D. Simons, John S. March

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

OBJECTIVE: To describe a manual-based intervention to address clinical crises and retain participants in the Treatment for Adolescents With Depression Study (TADS). METHOD: The use of adjunct services for attrition prevention (ASAP) is described for adolescents (ages 12-17 years) during the 12-week acute treatment in TADS, from 2000 to 2003. Logistic regression, controlling for site, was used to predict use. RESULTS: Of 439 enrolled participants, 17.8% (n = 78) used ASAP primarily for suicidality or worsening of depression. Of these, 46.2% continued in their assigned treatment through week 12, 47.4% received out-of-protocol treatment but continued participating in assessments, and 10.3% withdrew consent, including 3 who terminated treatment and withdrew consent on the same date. ASAP use did not differ between treatments (p =.97) and typically occurred early in treatment. At the end of the 12 weeks, 37.2% of participants using ASAP remained in their assigned treatment, although 80.8% continued participating in assessments. ASAP was associated with, at baseline, a higher severity of depression (p <.01), substance use (p <.01), and precontemplation level of change (p <.02). CONCLUSIONS: ASAP may be useful to retain adolescent participants and as a safety intervention in placebo-controlled trials. In clinical practice ASAP-like procedures may be useful to encourage adherence in patients engaging in long-term treatment. Copyright 2007

Original languageEnglish (US)
Pages (from-to)573-581
Number of pages9
JournalJournal of the American Academy of Child and Adolescent Psychiatry
Volume46
Issue number5
DOIs
StatePublished - May 2007

Keywords

  • Attrition
  • Depression
  • Retention
  • Treatment for Adolescents With Depression Study

ASJC Scopus subject areas

  • Developmental and Educational Psychology
  • Psychiatry and Mental health

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