A Mitochondrial view of aging, reactive oxygen species and metastatic cancer

Warren Ladiges, Jonathan Wanagat, Bradley Preston, Lawrence Loeb, Peter Rabinovitch

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations

Abstract

This perspective article highlights the growing evidence placing mitochondria and mitochondrial function at the center of cancer as an age-related disease. The discussion starts from the mitochondrial free radical hypothesis that predicts the involvement of endogenous mitochondrial reactive oxygen species (ROS) in cancer development and summarizes studies demonstrating the impact of the modulation of ROS levels on cancer development and metastasis. Cancer is fundamentally a complex interplay of cell growth, division, metastasis and death- processes connected to mitochondria through energy metabolism. Based on this evidence, therapeutics focused on mitochondrial function and mitochondrial ROS production are an attractive approach to modulating the progression of metastatic cancer and the general improvement of human health span.

Original languageEnglish (US)
Pages (from-to)462-465
Number of pages4
JournalAging cell
Volume9
Issue number4
DOIs
StatePublished - Aug 2010
Externally publishedYes

Keywords

  • Aging
  • Cancer
  • Mitochondria
  • ROS
  • Senescence

ASJC Scopus subject areas

  • Aging
  • Cell Biology

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