A modification of the dialytrode for simultaneous CNS recording and chemical stimulation

Kurtis G. Cornish, Richard E. Hall

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Currently, chemical stimulation of the brain is done either with a single cannula that is inserted at the time the drug is delivered or with two cannulae that permit perfusion of the area of interest. The dialytrode is a push-pull cannula consisting of two concentric tubes, a porous membrane covering the tip of the tubing and a platinum wire loop that extends around the membrane and is used for EEG recordings. Studies with the dialytrode indicate that while the membrane is relatively impermeable to bacteria, molecules the size of neurotransmitters pass easily through the membrane. Therefore, the dialytrode is well suited for chronic chemical stimulation studies.

Original languageEnglish (US)
Pages (from-to)389-392
Number of pages4
JournalPharmacology, Biochemistry and Behavior
Volume10
Issue number3
DOIs
StatePublished - Mar 1979

Keywords

  • CNS recording
  • Chemical stimulation
  • Dialytrode

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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