Abstract
Currently, chemical stimulation of the brain is done either with a single cannula that is inserted at the time the drug is delivered or with two cannulae that permit perfusion of the area of interest. The dialytrode is a push-pull cannula consisting of two concentric tubes, a porous membrane covering the tip of the tubing and a platinum wire loop that extends around the membrane and is used for EEG recordings. Studies with the dialytrode indicate that while the membrane is relatively impermeable to bacteria, molecules the size of neurotransmitters pass easily through the membrane. Therefore, the dialytrode is well suited for chronic chemical stimulation studies.
Original language | English (US) |
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Pages (from-to) | 389-392 |
Number of pages | 4 |
Journal | Pharmacology, Biochemistry and Behavior |
Volume | 10 |
Issue number | 3 |
DOIs | |
State | Published - Mar 1979 |
Externally published | Yes |
Keywords
- CNS recording
- Chemical stimulation
- Dialytrode
ASJC Scopus subject areas
- Biochemistry
- Toxicology
- Pharmacology
- Clinical Biochemistry
- Biological Psychiatry
- Behavioral Neuroscience