Abstract
MO calculations using the ω Hückel LCAO technique have been performed on several 3-alkylsdnones. Energy calculatioins permit predictions for protonation of the number 2 N-atom, nucleophilic attack at the number 5 C-atom, electrophilic attack at the number 4 C-atom, and free-radical attack at the number 4 C-atom. Supporting evidence for these predictions is discussed, and mechanisms of base- and acid-catalyzed hydrolysis are proposed.
Original language | English (US) |
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Pages (from-to) | 1673-1685 |
Number of pages | 13 |
Journal | Tetrahedron |
Volume | 24 |
Issue number | 4 |
DOIs | |
State | Published - 1968 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry