A mouse chromosome 17 gene encodes a testes-specific transcript with unusual properties

Nora Sarvetnick, Jen Yue Tsai, Howard Fox, Stephen H. Pilder, Lee M. Silver

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

We have characterized a novel mouse gene (D17Si11) on chromosome 17 that expresses a major transcript observed uniquely in the testes. The D17Si11 locus has been mapped to the central region of chromosome 17 between H-2 and C3. Sequence analysis demonstrates several unusual features of this locus and its transcript: first is the presence of complementary sets of alternating purine and pyrmidine residues within the 3′ region of the transcript that could form double-stranded, hairpin-like secondary structures with properties similar to that of Z-DNA; second is the existence of a hypothetical, long open reading frame in the nucleotide strand that is complementary to the testes transcripts. This complementary strand open reading frame is three times the size of the longest potential open reading frame present in the transcript itself. Although a function for D17Si11 has yet to be determined, the gene is relatively non-polymorphic in mice and appears conserved in mammals.

Original languageEnglish (US)
Pages (from-to)34-41
Number of pages8
JournalImmunogenetics
Volume30
Issue number1
DOIs
StatePublished - Jul 1 1989

ASJC Scopus subject areas

  • Immunology
  • Genetics

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