A mouse model for studying post-acute arthritis of chikungunya

Aileen Y. Chang, Sarah R. Tritsch, Abigail J. Porzucek, Arnold M. Schwartz, Margaux Seyler-Schmidt, Arielle Glass, Patricia S. Latham, St Patrick Reid, Gary L. Simon, Christopher N. Mores

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Chikungunya virus (CHIKV) was introduced to the Americas in 2013, causing two million infections across over thirty countries. CHIKV causes a chronic debilitating arthritis in one fourth of infected individuals and currently evidence-based targeted therapies for the treatment of CHIKV arthritis are lacking. Multiple mouse models of chikungunya have been developed to study acute CHIKV infection. In humans, post-CHIKV arthritis may persist for months to years after viremia from a CHIKV infection has resolved. Therefore, the development of a mouse model of post-acute arthritis of chikungunya may facilitate the study of potential novel therapeutics for this arthritis. In this article we describe the development of a wild-type immunocompetent C57BL/6 mouse model for post-acute arthritis of chikungunya, including a histologic inflammation scoring system, as well as suggestions for how this mouse model may be used to examine the efficacy of novel therapies for CHIKV arthritis.

Original languageEnglish (US)
Article number1998
JournalMicroorganisms
Volume9
Issue number9
DOIs
StatePublished - Sep 2021

Keywords

  • Arthritis
  • Arthritis therapy
  • Bone erosion
  • Chikungunya
  • Mouse model
  • Myositis
  • Synovitis

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Virology

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