A mouse model for studying post-acute arthritis of chikungunya

Aileen Y. Chang; Sarah R. Tritsch; Abigail J. Porzucek; Arnold M. Schwartz; Margaux Seyler-Schmidt; Arielle Glass; Patricia S. Latham; St Patrick Reid; Gary L. Simon; Christopher N. Mores

doi:10.3390/microorganisms9091998

A mouse model for studying post-acute arthritis of chikungunya

Aileen Y. Chang, Sarah R. Tritsch, Abigail J. Porzucek, Arnold M. Schwartz, Margaux Seyler-Schmidt, Arielle Glass, Patricia S. Latham, St Patrick Reid, Gary L. Simon, Christopher N. Mores

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Chikungunya virus (CHIKV) was introduced to the Americas in 2013, causing two million infections across over thirty countries. CHIKV causes a chronic debilitating arthritis in one fourth of infected individuals and currently evidence-based targeted therapies for the treatment of CHIKV arthritis are lacking. Multiple mouse models of chikungunya have been developed to study acute CHIKV infection. In humans, post-CHIKV arthritis may persist for months to years after viremia from a CHIKV infection has resolved. Therefore, the development of a mouse model of post-acute arthritis of chikungunya may facilitate the study of potential novel therapeutics for this arthritis. In this article we describe the development of a wild-type immunocompetent C57BL/6 mouse model for post-acute arthritis of chikungunya, including a histologic inflammation scoring system, as well as suggestions for how this mouse model may be used to examine the efficacy of novel therapies for CHIKV arthritis.

Original language	English (US)
Article number	1998
Journal	Microorganisms
Volume	9
Issue number	9
DOIs	https://doi.org/10.3390/microorganisms9091998
State	Published - Sep 2021

Keywords

Arthritis
Arthritis therapy
Bone erosion
Chikungunya
Mouse model
Myositis
Synovitis

ASJC Scopus subject areas

Microbiology
Microbiology (medical)
Virology

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10.3390/microorganisms9091998

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title = "A mouse model for studying post-acute arthritis of chikungunya",

abstract = "Chikungunya virus (CHIKV) was introduced to the Americas in 2013, causing two million infections across over thirty countries. CHIKV causes a chronic debilitating arthritis in one fourth of infected individuals and currently evidence-based targeted therapies for the treatment of CHIKV arthritis are lacking. Multiple mouse models of chikungunya have been developed to study acute CHIKV infection. In humans, post-CHIKV arthritis may persist for months to years after viremia from a CHIKV infection has resolved. Therefore, the development of a mouse model of post-acute arthritis of chikungunya may facilitate the study of potential novel therapeutics for this arthritis. In this article we describe the development of a wild-type immunocompetent C57BL/6 mouse model for post-acute arthritis of chikungunya, including a histologic inflammation scoring system, as well as suggestions for how this mouse model may be used to examine the efficacy of novel therapies for CHIKV arthritis.",

keywords = "Arthritis, Arthritis therapy, Bone erosion, Chikungunya, Mouse model, Myositis, Synovitis",

author = "Chang, {Aileen Y.} and Tritsch, {Sarah R.} and Porzucek, {Abigail J.} and Schwartz, {Arnold M.} and Margaux Seyler-Schmidt and Arielle Glass and Latham, {Patricia S.} and Reid, {St Patrick} and Simon, {Gary L.} and Mores, {Christopher N.}",

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year = "2021",

month = sep,

doi = "10.3390/microorganisms9091998",

language = "English (US)",

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AU - Chang, Aileen Y.

AU - Tritsch, Sarah R.

AU - Porzucek, Abigail J.

AU - Schwartz, Arnold M.

AU - Seyler-Schmidt, Margaux

AU - Glass, Arielle

AU - Latham, Patricia S.

AU - Reid, St Patrick

AU - Simon, Gary L.

AU - Mores, Christopher N.

PY - 2021/9

Y1 - 2021/9

N2 - Chikungunya virus (CHIKV) was introduced to the Americas in 2013, causing two million infections across over thirty countries. CHIKV causes a chronic debilitating arthritis in one fourth of infected individuals and currently evidence-based targeted therapies for the treatment of CHIKV arthritis are lacking. Multiple mouse models of chikungunya have been developed to study acute CHIKV infection. In humans, post-CHIKV arthritis may persist for months to years after viremia from a CHIKV infection has resolved. Therefore, the development of a mouse model of post-acute arthritis of chikungunya may facilitate the study of potential novel therapeutics for this arthritis. In this article we describe the development of a wild-type immunocompetent C57BL/6 mouse model for post-acute arthritis of chikungunya, including a histologic inflammation scoring system, as well as suggestions for how this mouse model may be used to examine the efficacy of novel therapies for CHIKV arthritis.

AB - Chikungunya virus (CHIKV) was introduced to the Americas in 2013, causing two million infections across over thirty countries. CHIKV causes a chronic debilitating arthritis in one fourth of infected individuals and currently evidence-based targeted therapies for the treatment of CHIKV arthritis are lacking. Multiple mouse models of chikungunya have been developed to study acute CHIKV infection. In humans, post-CHIKV arthritis may persist for months to years after viremia from a CHIKV infection has resolved. Therefore, the development of a mouse model of post-acute arthritis of chikungunya may facilitate the study of potential novel therapeutics for this arthritis. In this article we describe the development of a wild-type immunocompetent C57BL/6 mouse model for post-acute arthritis of chikungunya, including a histologic inflammation scoring system, as well as suggestions for how this mouse model may be used to examine the efficacy of novel therapies for CHIKV arthritis.

KW - Arthritis

KW - Arthritis therapy

KW - Bone erosion

KW - Chikungunya

KW - Mouse model

KW - Myositis

KW - Synovitis

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A mouse model for studying post-acute arthritis of chikungunya

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Keywords

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