TY - JOUR
T1 - A Multifunctional Polymeric Periodontal Membrane with Osteogenic and Antibacterial Characteristics
AU - Nasajpour, Amir
AU - Ansari, Sahar
AU - Rinoldi, Chiara
AU - Rad, Afsaneh Shahrokhi
AU - Aghaloo, Tara
AU - Shin, Su Ryon
AU - Mishra, Yogendra Kumar
AU - Adelung, Rainer
AU - Swieszkowski, Wojciech
AU - Annabi, Nasim
AU - Khademhosseini, Ali
AU - Moshaverinia, Alireza
AU - Tamayol, Ali
N1 - Funding Information:
A.N. and S.A. contributed equally to this work. This work was supported by ONR PECASE Award, and the National Institutes of Health (Grant Nos. HL092836, DE019024, EB012597, AR057837, DE021468, HL099073, EB008392, and DE023825). C.R. would like to thank the funding from the National Centre for Research and Development in the frame of START project (STRATEGMED1/233224/10/NCBR/2014). Y.K.M. and R.A. acknowledge the financial support from Deutsche Forschungsgemeinshaft (DFG) under schemes AD/183/10-1, AD 183/17-1, and under GRK 2154, Project P3. A.N. would like to acknowledge Dr. Anas Chalah (Harvard University) for inspiration during class discussion. A.T. acknowledges the financial support from Startup Fund provided by the University of Nebraska-Lincoln.
Publisher Copyright:
© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
PY - 2018/1/17
Y1 - 2018/1/17
N2 - Periodontitis is a prevalent chronic, destructive inflammatory disease affecting tooth-supporting tissues in humans. Guided tissue regeneration strategies are widely utilized for periodontal tissue regeneration generally by using a periodontal membrane. The main role of these membranes is to establish a mechanical barrier that prevents the apical migration of the gingival epithelium and hence allowing the growth of periodontal ligament and bone tissue to selectively repopulate the root surface. Currently available membranes have limited bioactivity and regeneration potential. To address such challenges, an osteoconductive, antibacterial, and flexible poly(caprolactone) (PCL) composite membrane containing zinc oxide (ZnO) nanoparticles is developed. The membranes are fabricated through electrospinning of PCL and ZnO particles. The physical properties, mechanical characteristics, and in vitro degradation of the engineered membrane are studied in detail. Also, the osteoconductivity and antibacterial properties of the developed membrane are analyzed in vitro. Moreover, the functionality of the membrane is evaluated with a rat periodontal defect model. The results confirmed that the engineered membrane exerts both osteoconductive and antibacterial properties, demonstrating its great potential for periodontal tissue engineering.
AB - Periodontitis is a prevalent chronic, destructive inflammatory disease affecting tooth-supporting tissues in humans. Guided tissue regeneration strategies are widely utilized for periodontal tissue regeneration generally by using a periodontal membrane. The main role of these membranes is to establish a mechanical barrier that prevents the apical migration of the gingival epithelium and hence allowing the growth of periodontal ligament and bone tissue to selectively repopulate the root surface. Currently available membranes have limited bioactivity and regeneration potential. To address such challenges, an osteoconductive, antibacterial, and flexible poly(caprolactone) (PCL) composite membrane containing zinc oxide (ZnO) nanoparticles is developed. The membranes are fabricated through electrospinning of PCL and ZnO particles. The physical properties, mechanical characteristics, and in vitro degradation of the engineered membrane are studied in detail. Also, the osteoconductivity and antibacterial properties of the developed membrane are analyzed in vitro. Moreover, the functionality of the membrane is evaluated with a rat periodontal defect model. The results confirmed that the engineered membrane exerts both osteoconductive and antibacterial properties, demonstrating its great potential for periodontal tissue engineering.
KW - electrospinning
KW - guided tissue regeneration
KW - osteoconductive
KW - periodontal regeneration
KW - zinc oxide
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U2 - 10.1002/adfm.201703437
DO - 10.1002/adfm.201703437
M3 - Article
AN - SCOPUS:85033203369
SN - 1616-301X
VL - 28
JO - Advanced Functional Materials
JF - Advanced Functional Materials
IS - 3
M1 - 1703437
ER -