A new approach to clustering biological data using message passing

Research output: Chapter in Book/Report/Conference proceedingConference contribution

9 Scopus citations

Abstract

Clustering algorithms are widely used in bioinformatics to classify data, as in the analysis of gene expression and in the building of phylogenetic trees. Biological data often describe parallel and spontaneous processes. To capture these features, we propose a new clustering algorithm that employs the concept of message passing. Message Passing Clustering (MPC) allows data objects to communicate with each other and produces clusters in parallel, thereby making the clustering process intrinsic. We have proved that MPC shares similarity with Hierarchical Clustering (HC) but offers significantly improved performance because it takes into account both local and global structure. We analyzed 35 sets of simulated dynamic gene expression data, achieving a 95% hit rate in which 639 genes out of total 674 genes were correctly clustered. We have also applied MPC to a real data set to build a phylogenetic tree from aligned mycobacterium sequences. The results show higher classification accuracies as compared to traditional clustering methods such as HC.

Original languageEnglish (US)
Title of host publicationProceedings - 2004 IEEE Computational Systems Bioinformatics Conference, CSB 2004
Pages493-494
Number of pages2
StatePublished - Dec 1 2004
EventProceedings - 2004 IEEE Computational Systems Bioinformatics Conference, CSB 2004 - Stanford, CA, United States
Duration: Aug 16 2004Aug 19 2004

Publication series

NameProceedings - 2004 IEEE Computational Systems Bioinformatics Conference, CSB 2004

Conference

ConferenceProceedings - 2004 IEEE Computational Systems Bioinformatics Conference, CSB 2004
CountryUnited States
CityStanford, CA
Period8/16/048/19/04

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ASJC Scopus subject areas

  • Engineering(all)

Cite this

Geng, H., Bastola, D., & Ali, H. (2004). A new approach to clustering biological data using message passing. In Proceedings - 2004 IEEE Computational Systems Bioinformatics Conference, CSB 2004 (pp. 493-494). (Proceedings - 2004 IEEE Computational Systems Bioinformatics Conference, CSB 2004).