@inproceedings{a1a51a5a45b945849341a08e6bc497cf,
title = "A new system for human microRNA functional evaluation and network",
abstract = "MicroRNAs are functionally important non-coding RNAs that silence host genes via destabilizing the mRNAs or preventing the translation. Given the far-reaching implication of microRNA regulation in human health, novel bioinformatics tools are desired to facilitate the mechanistic understanding of microRNA mediated gene regulation and its regulatory roles in human disease development. Most state-of-the-art computational methods focus on the functional inference through identifying microRNA targets and none has comprehensively investigated the functional similarity among microRNAs. Here we present a new method to quantitatively measure the functional relevance among microRNAs that is solely based on the Gene Ontology and integrated functional annotation data from public pathways and PFam gene databases. In this study, we further demonstrated the use of the derived microRNA pairwise similarities to investigate the cooperative microRNA modules and construct the genome scale microRNA mediated gene network in human. The complete results and the similarity assessment system can be freely accessed at (http://sbbi.unl.edu/microRNASim)",
keywords = "Functional similarity, Gene Ontology, Gene regulation network, MicroRNA, Semantic Similarity",
author = "Jiachun Han and Jiang Shu and Juan Cui",
note = "Funding Information: We would like to thank all SBBI members who have been involved in this work. This research is supported by the NIH funded COBRE grant (1P20GM104320) and the Tobacco Settlement Fund as part of Cui's startup grant support Publisher Copyright: {\textcopyright} 2016 IEEE.; 2016 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2016 ; Conference date: 15-12-2016 Through 18-12-2016",
year = "2017",
month = jan,
day = "17",
doi = "10.1109/BIBM.2016.7822531",
language = "English (US)",
series = "Proceedings - 2016 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2016",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
pages = "278--283",
editor = "Kevin Burrage and Qian Zhu and Yunlong Liu and Tianhai Tian and Yadong Wang and Hu, {Xiaohua Tony} and Qinghua Jiang and Jiangning Song and Shinichi Morishita and Kevin Burrage and Guohua Wang",
booktitle = "Proceedings - 2016 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2016",
}