A new technology for detecting cerebral blood flow: A comparative study of ultrasound tagged NIRS and 133Xe-SPECT

Henrik W. Schytz, Song Guo, Lars T. Jensen, Moshe Kamar, Asaph Nini, Daryl R. Gress, Messoud Ashina

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


There is a need for real-time non-invasive, continuous monitoring of cerebral blood flow (CBF) during surgery, in intensive care units and clinical research. We investigated a new non-invasive hybrid technology employing ultrasound tagged near infrared spectroscopy (UT-NIRS) that may estimate changes in CBF using a cerebral blood flow index (CFI). Changes over time for UT-NIRS CFI and 133Xenon single photon emission computer tomography ( 133Xe-SPECT) CBF data were assessed in 10 healthy volunteers after an intravenous bolus of acetazolamide. UT-NIRS CFI was measured continuously and SPECT CBF was measured at baseline, 15 and 60 min after acetazolamide. We found significant changes over time in CFI by UT-NIRS and CBF by SPECT after acetazolamide (P ≤ 0.001). Post hoc tests showed a significant increase in CFI (P = 0.011) and SPECT CBF (P < 0.001) at 15 min after acetazolamide injection. There was a significant correlation between CFI and SPECT CBF values (r = 0.67 and P ≤ 0.033) at 15 min, but not at 60 min (P ≥ 0.777). UT-NIRS detected an increase in CFI following an acetazolamide bolus, which correlated with CBF measured with 133Xe-SPECT. This study demonstrates that UT-NIRS technology may be a promising new technique for non-invasive and real-time bedside CBF monitoring.

Original languageEnglish (US)
Pages (from-to)139-145
Number of pages7
JournalNeurocritical Care
Issue number1
StatePublished - Aug 2012
Externally publishedYes


  • Acetazolamide
  • Cerebral blood flow
  • Monitoring
  • Ultrasound tagged near infrared spectroscopy
  • Xenon single photon emission computer tomography

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Clinical Neurology


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