A non-cardiovirulent strain of coxsackievirus B3 causes myocarditis in mice with severe combined immunodeficiency syndrome

G. Hufnagel, N. Chapman, S. Tracy

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

The most extensively studied animal model of coxsackievirus B3 (CVB3)-induced inflammatory heart muscle disease is the murine model. In the acute and chronic phase of the disease, it has been suggested that autoimmune mechanisms play a major role in the pathogenesis of the disease. In this study, C3H mice without functional T- and B-lymphocytes (C3H SCID) were inoculated either with a cardiovirulent (CVB3/20) or a non-cardiovirulent (CVB3/0) strain of coxsackievirus B3. Both viruses caused myocarditis in SCID mice. Furthermore, it could be demonstrated, that CVB3/0 had mutated to a cardiovirulent phenotype, able to cause myocarditis in immunocompetent mice.

Original languageEnglish (US)
Pages (from-to)18-19
Number of pages2
JournalEuropean Heart Journal
Volume16
Issue numberSUPPL. O
DOIs
StatePublished - 1995

Keywords

  • Coxsackievirus B3
  • Enterovirus
  • Inflammatory heart disease
  • Mice
  • Myocarditis
  • SCID

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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