@article{d5a34f14538745fdb9c4dcdc209dfd0a,
title = "A novel adenovirus isolated from the Egyptian fruit bat in South Africa is closely related to recent isolates from China",
abstract = "Recently a number of novel adenoviruses have been isolated from diverse bat species and from diverse geographical locations. We describe the isolation of a novel adenovirus (Family Adenoviridae, genus Mastadenovirus) from a pool of liver and spleen tissue of an apparently healthy wild-caught Egyptian fruit bat (Rousettus aegyptiacus) in South Africa. Genetically the virus is most closely related to four mastadenoviruses recently isolated in China, from Miniopterus schreibersi and Rousettus leschenaultii bats, which are highly divergent from previously identified bat adenoviruses. The length of the Rousettus aegyptiacus adenovirus-3085 (RaegAdV-3085) genome, at 29,342 bp is similar to its closest relatives, and contains 27 open reading frames. The RaegAdV-3085 genome has a low G + C content (36.4%) relative to other viruses in the genus (between 43.6 and 63.9%) but similar to its closest relatives. The inverted terminal repeat (ITR) of RaegAdV-3085 is only 40 bp compared to between 61 and 178 bp of its closest relatives. The discovery of RaegAdV-3085 expands the diversity of known adenoviruses in bats and might represent a member of a new mastadenovirus species in bats.",
author = "{Jansen Van Vuren}, Petrus and Mushal Allam and Wiley, {Michael R.} and Arshad Ismail and Nadia Storm and Monica Birkhead and Wanda Markotter and Gustavo Palacios and Paweska, {Janusz T.}",
note = "Funding Information: The authors would like to thank the following individuals for their contributions towards fieldwork and technical assistance: Busi Mogodi, Justice Kgatitsoe, Alan Kemp, Stewart McCulloch, Terence Scott, Joe Kgaladi, Marinda Mortlock, Marike Geldenhuys, Jessica Coertse and Andre Coetzer. The project is jointly funded by the following grants awarded to: Janusz T. Paweska (CDC Global Disease Detection program, GDD 5U19 GH000571– 05/96667) and Petrus Jansen van Vuren (South African National Research Foundation, Incentive Funding for Rated Researchers, Grant UID 85544). This work was financially supported in part by the National Research Foundation (NRF) of South Africa: the South African Research Chair held by WM, grant no. 98339, as well as grant numbers 92524, 85756, and 91496. The grant holders acknowledge that opinions, findings and conclusions or recommendations expressed in any publication generated by GDD and NRF supported research are those of the authors and that the GDD and NRF accept no liability whatsoever in this regard. Publisher Copyright: {\textcopyright} 2018 The Author(s).",
year = "2018",
month = dec,
day = "1",
doi = "10.1038/s41598-018-27836-w",
language = "English (US)",
volume = "8",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",
}