A novel locus for autosomal dominant nonsyndromic hearing loss, DFNA13, maps to chromosome 6p

M. R. Brown, M. S. Tomek, L. Van Laer, S. Smith, J. B. Kenyon, G. Van Camp, R. J.H. Smith

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

Nonsyndromic hearing loss (NSHL) is the most common type of hearing impairment in the elderly. Environmental and hereditary factors play an etiologic role, although the relative contribution of each is unknown. To date, 39 NSHL genes have been localized. Twelve produce autosomal dominant hearing loss, most frequently postlingual in onset and progressive in nature. We have ascertained a large, multigenerational family in which a gene for autosomal dominant NSHL is segregating. Affected individuals experience progressive hearing loss beginning in the 2d-4th decades, eventually making the use of amplification mandatory. A novel locus, DFNA13, was identified on chromosome 6p; the disease gene maps to a 4-cM interval flanked by D6S1663 and D6S1691, with a maximum two-point LOD score of 6.409 at D6S299.

Original languageEnglish (US)
Pages (from-to)924-927
Number of pages4
JournalAmerican Journal of Human Genetics
Volume61
Issue number4
DOIs
StatePublished - Oct 1997

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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