A novel respiratory model of infection with monkeypox virus in cynomolgus macaques

Arthur J. Goff, Jennifer Chapman, Chad Foster, Carly Wlazlowski, Joshua Shamblin, Kenny Lin, Norman Kreiselmeier, Eric Mucker, Jason Paragas, James Lawler, Lisa Hensley

Research output: Contribution to journalArticle

38 Scopus citations

Abstract

Variola, the causative agent of smallpox, and the related monkeypox virus are both select agents that, if purposefully released, would cause public panic and social disruption. For this reason research continues in the areas of animal model and therapeutic development. Orthopoxviruses show a widely varying degree of host specificity, making development of accurate animal models difficult. In this paper, we demonstrate a novel respiratory infection technique that resulted in "classic" orthopox disease in nonhuman primates and takes the field of research one step closer to a better animal model.

Original languageEnglish (US)
Pages (from-to)4898-4909
Number of pages12
JournalJournal of virology
Volume85
Issue number10
DOIs
StatePublished - May 1 2011

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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    Goff, A. J., Chapman, J., Foster, C., Wlazlowski, C., Shamblin, J., Lin, K., Kreiselmeier, N., Mucker, E., Paragas, J., Lawler, J., & Hensley, L. (2011). A novel respiratory model of infection with monkeypox virus in cynomolgus macaques. Journal of virology, 85(10), 4898-4909. https://doi.org/10.1128/JVI.02525-10